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ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways

OBJECTIVE: The phenomenon that cancer cells avidly exhibit glycolysis with lactate secretion and decrease in mitochondrial activity under aerobic conditions is known historically as the Warburg effect. Rho GTPase-activating protein 4 (ARHGAP4) is an important negative regulator of the Rho signaling...

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Detalles Bibliográficos
Autores principales:	Shen, Yehua, Chen, Gang, Zhuang, Liping, Xu, Litao, Lin, Junhua, Liu, Luming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611502/ https://www.ncbi.nlm.nih.gov/pubmed/31303760 http://dx.doi.org/10.2147/OTT.S207560

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