The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding

Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans. With these procedures, animals are offered a choice between high-effort instrumental actions leading to highly valued reinforcers vs. low effort/low reward options. Several prev...

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Detalles Bibliográficos
Autores principales: Rotolo, Renee A., Dragacevic, Vladimir, Kalaba, Predrag, Urban, Ernst, Zehl, Martin, Roller, Alexander, Wackerlig, Judith, Langer, Thierry, Pistis, Marco, De Luca, Maria Antonietta, Caria, Francesca, Schwartz, Rebecca, Presby, Rose E., Yang, Jen-Hau, Samels, Shanna, Correa, Merce, Lubec, Gert, Salamone, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611521/
https://www.ncbi.nlm.nih.gov/pubmed/31316379
http://dx.doi.org/10.3389/fphar.2019.00682

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