Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors

CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the development of biologics that inhibit SIRPα engagem...

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Detalles Bibliográficos
Autores principales: Miller, Thomas W., Amason, Joshua D., Garcin, Elsa D., Lamy, Laurence, Dranchak, Patricia K., Macarthur, Ryan, Braisted, John, Rubin, Jeffrey S., Burgess, Teresa L., Farrell, Catherine L., Roberts, David D., Inglese, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611588/
https://www.ncbi.nlm.nih.gov/pubmed/31276567
http://dx.doi.org/10.1371/journal.pone.0218897

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