Cargando…

The role of thrombin in the pathogenesis of diabetic neuropathy

Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shavit-Stein, Efrat, Aronovich, Ramona, Sylantiev, Constantin, Gofrit, Shany Guly, Chapman, Joab, Dori, Amir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611599/ https://www.ncbi.nlm.nih.gov/pubmed/31276565 http://dx.doi.org/10.1371/journal.pone.0219453

Ejemplares similares

Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis
por: Shavit-Stein, Efrat, et al.
Publicado: (2019)

PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy
por: Golderman, Valery, et al.
Publicado: (2023)

Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume
por: Shavit-Stein, Efrat, et al.
Publicado: (2021)

Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
por: Berkowitz, Shani, et al.
Publicado: (2021)

Treatment of Diabetic Neuropathy with A Novel PAR1-Targeting Molecule
por: Shavit-Stein, Efrat, et al.
Publicado: (2020)

Thrombin Activity in Rodent and Human Skin: Modified by Inflammation and Correlates with Innervation
por: Golderman, Valery, et al.
Publicado: (2022)

Modulation of the Thrombin Pathway Restores LTP in a Pilocarpine Mice Model of Status Epilepticus
por: Shavit-Stein, Efrat, et al.
Publicado: (2022)

Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus
por: Shavit-Stein, Efrat, et al.
Publicado: (2021)

The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases
por: Gofrit, Shany G., et al.
Publicado: (2019)

LPS-Induced Coagulation and Neuronal Damage in a Mice Model Is Attenuated by Enoxaparin
por: Berkowitz, Shani, et al.
Publicado: (2022)

Factor VII, EPCR, aPC Modulators: novel treatment for neuroinflammation
por: Golderman, Valery, et al.
Publicado: (2022)

Markers for neural degeneration and regeneration: novel highly sensitive methods for the measurement of thrombin and activated protein C in human cerebrospinal fluid
por: Gerasimov, Alexandra, et al.
Publicado: (2021)

Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke
por: Stein, Efrat Shavit, et al.
Publicado: (2015)

A Novel Highly Sensitive Method for Measuring Inflammatory Neural-Derived APC Activity in Glial Cell Lines, Mouse Brain and Human CSF
por: Golderman, Valery, et al.
Publicado: (2020)

Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis
por: Shavit-Stein, Efrat, et al.
Publicado: (2020)

Prolonged systemic inflammation persistently modifies synaptic plasticity in the hippocampus: modulation by the stress hormones
por: Maggio, Nicola, et al.
Publicado: (2013)

Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment
por: Shavit Stein, Efrat, et al.
Publicado: (2018)

A Linear Temporal Increase in Thrombin Activity and Loss of Its Receptor in Mouse Brain following Ischemic Stroke
por: Bushi, Doron, et al.
Publicado: (2017)

Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology
por: Koren-Iton, Amit, et al.
Publicado: (2020)

The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro
por: Golderman, Valery, et al.
Publicado: (2016)

A Novel Compound Targeting Protease Receptor 1 Activators for the Treatment of Glioblastoma
por: Shavit-Stein, Efrat, et al.
Publicado: (2018)

Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis
por: Aharoni, Rina, et al.
Publicado: (2021)

Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus
por: Ben Shimon, Marina, et al.
Publicado: (2017)

Thrombin regulation of synaptic transmission and plasticity: implications for health and disease
por: Ben Shimon, Marina, et al.
Publicado: (2015)

Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury
por: Ben Shimon, Marina, et al.
Publicado: (2020)

Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers
por: Goldberg, Zehavit, et al.
Publicado: (2022)

Pathogenesis of Painful Diabetic Neuropathy
por: Aslam, Amir, et al.
Publicado: (2014)

Protease Activated Receptor 2 (PAR2) Induces Long-Term Depression in the Hippocampus through Transient Receptor Potential Vanilloid 4 (TRPV4)
por: Shavit-Stein, Efrat, et al.
Publicado: (2017)

Role of Inflammation in the Pathogenesis of Diabetic Peripheral Neuropathy
por: Ristikj-Stomnaroska, Daniela, et al.
Publicado: (2019)

Diagnostic Challenges and Solutions in Systemic Amyloidosis
por: Goldis, Rivka, et al.
Publicado: (2023)

The Characteristics of Thrombin in Osteoarthritic Pathogenesis and Treatment
por: Chou, Pei-Yu, et al.
Publicado: (2014)

Characterization of Meningitis and Meningoencephalitis in the Israeli Defense Forces From 2004 to 2015: A Population-Based Study
por: Gofrit, Shany Guly, et al.
Publicado: (2022)

Pros and cons of a prion-like pathogenesis in Parkinson's disease
por: Hilker, Ruediger, et al.
Publicado: (2011)

The Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina
por: Oshitari, Toshiyuki
Publicado: (2021)

Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis
por: Zhang, Yichen, et al.
Publicado: (2023)

Post Stroke Seizures and Epilepsy: From Proteases to Maladaptive Plasticity
por: Altman, Keren, et al.
Publicado: (2019)

Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin
por: Maggio, Nicola, et al.
Publicado: (2018)

Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy
por: Kasznicki, Jacek, et al.
Publicado: (2012)

Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy
por: Yang, Cunqing, et al.
Publicado: (2023)

Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy
por: Lupachyk, Sergey, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_m0gdcb4fhnhap9om5tmg3knnib