High-level expression of biologically active human follicle stimulating hormone in the Chinese hamster ovary cell line by a pair of tricistronic and monocistronic vectors

Recombinant human follicle stimulating hormone (FSH), produced in Chinese hamster ovary (CHO) cells, is widely used for treatment of fertility disorders and is subject to biosimilars development. Cell lines with high specific productivities may simplify the FSH production process. Here, we used our...

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Detalles Bibliográficos
Autores principales: Orlova, Nadezhda A., Kovnir, Sergey V., Khodak, Yulia A., Polzikov, Mikhail A., Nikitina, Victoria A., Skryabin, Konstantin G., Vorobiev, Ivan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611665/
https://www.ncbi.nlm.nih.gov/pubmed/31276557
http://dx.doi.org/10.1371/journal.pone.0219434

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