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Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

Glycosylphosphatidylinositol (GPI) anchors attach nearly 150 proteins to the cell membrane. Patients with pathogenic variants in GPI biosynthesis genes develop diverse phenotypes including seizures, dysmorphic facial features and cleft palate through an unknown mechanism. We identified a novel mouse...

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Detalles Bibliográficos
Autores principales:	Lukacs, Marshall, Roberts, Tia, Chatuverdi, Praneet, Stottmann, Rolf W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611694/ https://www.ncbi.nlm.nih.gov/pubmed/31232685 http://dx.doi.org/10.7554/eLife.45248

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