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DNA damage detection in nucleosomes involves DNA register shifting

Access to DNA packaged in nucleosomes is critical for gene regulation, DNA replication and repair. In humans, the UV-DDB complex detects ultraviolet light induced pyrimidine dimers throughout the genome, yet it remains unknown how these lesions are recognised in chromatin, where nucleosomes restrict...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Syota, Cavadini, Simone, Bunker, Richard D., Grand, Ralph S., Potenza, Alessandro, Rabl, Julius, Yamamoto, Junpei, Schenk, Andreas D., Schübeler, Dirk, Iwai, Shigenori, Sugasawa, Kaoru, Kurumizaka, Hitoshi, Thomä, Nicolas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611726/ https://www.ncbi.nlm.nih.gov/pubmed/31142837 http://dx.doi.org/10.1038/s41586-019-1259-3

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