Adenosine A(2A) receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes

Niemann Pick type C (NPC) disease is a rare neurovisceral disorder. Mutations in npc1 gene induce an intracellular accumulation of unesterified cholesterol in the endosomal/lysosomal system causing cell death. We recently showed that stimulation of adenosine A(2A) receptors (A(2A)R) restores cholest...

Descripción completa

Detalles Bibliográficos
Autores principales: De Nuccio, Chiara, Bernardo, Antonietta, Ferrante, Antonella, Pepponi, Rita, Martire, Alberto, Falchi, Mario, Visentin, Sergio, Popoli, Patrizia, Minghetti, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611770/
https://www.ncbi.nlm.nih.gov/pubmed/31278313
http://dx.doi.org/10.1038/s41598-019-46268-8

Ejemplares similares

Ejemplares similares