Comprehensive Metabolomic Analysis of IDH1(R132H) Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency

Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation have alterations in several enzyme activities, resulting in various metabolic changes. The aim of this study was to determine a mechanism for the better prognosis of gliomas with IDH mutation by performing metabolomic analysis. To understand th...

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Detalles Bibliográficos
Autores principales: Miyata, Satsuki, Tominaga, Kaoru, Sakashita, Eiji, Urabe, Masashi, Onuki, Yoshiyuki, Gomi, Akira, Yamaguchi, Takashi, Mieno, Makiko, Mizukami, Hiroaki, Kume, Akihiro, Ozawa, Keiya, Watanabe, Eiju, Kawai, Kensuke, Endo, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611790/
https://www.ncbi.nlm.nih.gov/pubmed/31278288
http://dx.doi.org/10.1038/s41598-019-46217-5

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