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Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders
Maternal obesity often occurs together with comorbid diabetes and hypertensive disorders. All three conditions are independently associated with negative perinatal outcomes. Our objective was to determine the risk and burden of adverse perinatal outcome that could be attributed to maternal obesity i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611811/ https://www.ncbi.nlm.nih.gov/pubmed/31278325 http://dx.doi.org/10.1038/s41598-019-46179-8 |
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author | Aubry, Evelyne M. Oelhafen, Stephan Fankhauser, Niklaus Raio, Luigi Cignacco, Eva L. |
author_facet | Aubry, Evelyne M. Oelhafen, Stephan Fankhauser, Niklaus Raio, Luigi Cignacco, Eva L. |
author_sort | Aubry, Evelyne M. |
collection | PubMed |
description | Maternal obesity often occurs together with comorbid diabetes and hypertensive disorders. All three conditions are independently associated with negative perinatal outcomes. Our objective was to determine the risk and burden of adverse perinatal outcome that could be attributed to maternal obesity in combination with a comorbid status. We analyzed data from 324′664 singleton deliveries in Switzerland between 2005 and 2016. For the association of maternal obesity in the presence or absence of comorbidities with various perinatal outcomes, we estimated adjusted relative risk (RR) using multivariable regression modeling and determined the multivariable-adjusted attributable fraction of the population (AFp). Obesity was a main predictor for macrosomia, fracture of the clavicle, failure to progress in labor and prolonged labor. By stratifying women based on comorbidities, we identified significantly increased risk for preterm birth and early neonatal death only for women diagnosed with a comorbidity. However, various other outcomes were independently associated with either obesity or comorbidities. The AFp showed greatest reduction in comorbidities (15.4/15.0/13.2%), in macrosomia (6.3%) and in shoulder dystocia (4.8%) if all women were to become non-obese. We suggest that comorbidities such as diabetes and hypertensive disorders should be considered when relating maternal obesity to adverse perinatal outcomes. |
format | Online Article Text |
id | pubmed-6611811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66118112019-07-15 Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders Aubry, Evelyne M. Oelhafen, Stephan Fankhauser, Niklaus Raio, Luigi Cignacco, Eva L. Sci Rep Article Maternal obesity often occurs together with comorbid diabetes and hypertensive disorders. All three conditions are independently associated with negative perinatal outcomes. Our objective was to determine the risk and burden of adverse perinatal outcome that could be attributed to maternal obesity in combination with a comorbid status. We analyzed data from 324′664 singleton deliveries in Switzerland between 2005 and 2016. For the association of maternal obesity in the presence or absence of comorbidities with various perinatal outcomes, we estimated adjusted relative risk (RR) using multivariable regression modeling and determined the multivariable-adjusted attributable fraction of the population (AFp). Obesity was a main predictor for macrosomia, fracture of the clavicle, failure to progress in labor and prolonged labor. By stratifying women based on comorbidities, we identified significantly increased risk for preterm birth and early neonatal death only for women diagnosed with a comorbidity. However, various other outcomes were independently associated with either obesity or comorbidities. The AFp showed greatest reduction in comorbidities (15.4/15.0/13.2%), in macrosomia (6.3%) and in shoulder dystocia (4.8%) if all women were to become non-obese. We suggest that comorbidities such as diabetes and hypertensive disorders should be considered when relating maternal obesity to adverse perinatal outcomes. Nature Publishing Group UK 2019-07-05 /pmc/articles/PMC6611811/ /pubmed/31278325 http://dx.doi.org/10.1038/s41598-019-46179-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Aubry, Evelyne M. Oelhafen, Stephan Fankhauser, Niklaus Raio, Luigi Cignacco, Eva L. Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
title | Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
title_full | Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
title_fullStr | Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
title_full_unstemmed | Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
title_short | Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
title_sort | adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611811/ https://www.ncbi.nlm.nih.gov/pubmed/31278325 http://dx.doi.org/10.1038/s41598-019-46179-8 |
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