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Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits
Fruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611835/ https://www.ncbi.nlm.nih.gov/pubmed/31316897 http://dx.doi.org/10.1016/j.toxrep.2019.06.017 |
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author | Palozi, Rhanany Alan Calloi Guarnier, Lucas Pires Romão, Paulo Vitor Moreira Nocchi, Samara Requena dos Santos, Carlos Calixto Lourenço, Emerson Luiz Botelho Silva, Denise Brentan Gasparotto, Francielly Mourão Gasparotto Junior, Arquimedes |
author_facet | Palozi, Rhanany Alan Calloi Guarnier, Lucas Pires Romão, Paulo Vitor Moreira Nocchi, Samara Requena dos Santos, Carlos Calixto Lourenço, Emerson Luiz Botelho Silva, Denise Brentan Gasparotto, Francielly Mourão Gasparotto Junior, Arquimedes |
author_sort | Palozi, Rhanany Alan Calloi |
collection | PubMed |
description | Fruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora in New Zealand rabbits. First, an ethanol extract (EEPC) was selected for the pharmacological experiments and chemical characterization. Then, different groups of rabbits were orally treated with EEPC (200 and 2000 mg/kg) or vehicle. Acute behavioral and physiological alterations in the modified Irwin test, respiratory rate, arterial blood gas, and various cardiovascular parameters (i.e., heart rate, blood pressure, and electrocardiography) were evaluated. The main secondary metabolites that were identified in EEPC were ellagic acid, gallic acid, O-deoxyhexosyl quercetin, and the anthocyanin O-hexosyl cyanidin. No significant behavioral or physiological changes were observed in any of the groups. None of the doses of EEPC affected respiratory rate or arterial blood gas, with no changes on blood pressure or electrocardiographic parameters. The present study showed that EEPC did not cause any significant changes in respiratory, cardiovascular, or central nervous system function. These data provide scientific evidence of the effects of this species and important safety data for its clinical use. |
format | Online Article Text |
id | pubmed-6611835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-66118352019-07-17 Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits Palozi, Rhanany Alan Calloi Guarnier, Lucas Pires Romão, Paulo Vitor Moreira Nocchi, Samara Requena dos Santos, Carlos Calixto Lourenço, Emerson Luiz Botelho Silva, Denise Brentan Gasparotto, Francielly Mourão Gasparotto Junior, Arquimedes Toxicol Rep Article Fruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora in New Zealand rabbits. First, an ethanol extract (EEPC) was selected for the pharmacological experiments and chemical characterization. Then, different groups of rabbits were orally treated with EEPC (200 and 2000 mg/kg) or vehicle. Acute behavioral and physiological alterations in the modified Irwin test, respiratory rate, arterial blood gas, and various cardiovascular parameters (i.e., heart rate, blood pressure, and electrocardiography) were evaluated. The main secondary metabolites that were identified in EEPC were ellagic acid, gallic acid, O-deoxyhexosyl quercetin, and the anthocyanin O-hexosyl cyanidin. No significant behavioral or physiological changes were observed in any of the groups. None of the doses of EEPC affected respiratory rate or arterial blood gas, with no changes on blood pressure or electrocardiographic parameters. The present study showed that EEPC did not cause any significant changes in respiratory, cardiovascular, or central nervous system function. These data provide scientific evidence of the effects of this species and important safety data for its clinical use. Elsevier 2019-06-28 /pmc/articles/PMC6611835/ /pubmed/31316897 http://dx.doi.org/10.1016/j.toxrep.2019.06.017 Text en © 2019 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Palozi, Rhanany Alan Calloi Guarnier, Lucas Pires Romão, Paulo Vitor Moreira Nocchi, Samara Requena dos Santos, Carlos Calixto Lourenço, Emerson Luiz Botelho Silva, Denise Brentan Gasparotto, Francielly Mourão Gasparotto Junior, Arquimedes Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
title | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
title_full | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
title_fullStr | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
title_full_unstemmed | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
title_short | Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits |
title_sort | pharmacological safety of plinia cauliflora (mart.) kausel in rabbits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611835/ https://www.ncbi.nlm.nih.gov/pubmed/31316897 http://dx.doi.org/10.1016/j.toxrep.2019.06.017 |
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