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Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

Type III-A CRISPR-Cas systems are prokaryotic RNA-guided adaptive immune systems that use a protein-RNA complex, Csm, for transcription-dependent immunity against foreign DNA. Csm can cleave RNA and single-stranded DNA (ssDNA), but whether it targets one or both nucleic acids during transcription el...

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Detalles Bibliográficos
Autores principales:	Liu, Tina Y., Liu, Jun-Jie, Aditham, Abhishek J., Nogales, Eva, Doudna, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611850/ https://www.ncbi.nlm.nih.gov/pubmed/31278272 http://dx.doi.org/10.1038/s41467-019-10780-2

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