Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for immune suppression, arginase-1 (ARG1)-carrying small extracellular vesicles (EVs) emerge as important contributors to tumor growth and tumor escape fr...

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Detalles Bibliográficos
Autores principales: Czystowska-Kuzmicz, Malgorzata, Sosnowska, Anna, Nowis, Dominika, Ramji, Kavita, Szajnik, Marta, Chlebowska-Tuz, Justyna, Wolinska, Ewa, Gaj, Pawel, Grazul, Magdalena, Pilch, Zofia, Zerrouqi, Abdessamad, Graczyk-Jarzynka, Agnieszka, Soroczynska, Karolina, Cierniak, Szczepan, Koktysz, Robert, Elishaev, Esther, Gruca, Slawomir, Stefanowicz, Artur, Blaszczyk, Roman, Borek, Bartlomiej, Gzik, Anna, Whiteside, Theresa, Golab, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611910/
https://www.ncbi.nlm.nih.gov/pubmed/31278254
http://dx.doi.org/10.1038/s41467-019-10979-3

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