Efficient Generation of Pathogenic A-to-G Mutations in Human Tripronuclear Embryos via ABE-Mediated Base Editing

Base editing systems show their power in modeling and correcting the pathogenic mutations of genetic diseases. Previous studies have already demonstrated the editing efficiency of BE3-mediated C-to-T conversion in human embryos. However, the precision and efficiency of a recently developed adenine b...

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Detalles Bibliográficos
Autores principales: Li, Guanglei, Liu, Xinyi, Huang, Shisheng, Zeng, Yanting, Yang, Guang, Lu, Zongyang, Zhang, Yu, Ma, Xu, Wang, Lisheng, Huang, Xingxu, Liu, Jianqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611966/
https://www.ncbi.nlm.nih.gov/pubmed/31279230
http://dx.doi.org/10.1016/j.omtn.2019.05.021

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