Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylation is decreased in the affected neuronal tissues. Histone acetylation is controlled by the...

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Detalles Bibliográficos
Autores principales: Rossaert, Elisabeth, Pollari, Eveliina, Jaspers, Tom, Van Helleputte, Lawrence, Jarpe, Matthew, Van Damme, Philip, De Bock, Katrien, Moisse, Matthieu, Van Den Bosch, Ludo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612190/
https://www.ncbi.nlm.nih.gov/pubmed/31277703
http://dx.doi.org/10.1186/s40478-019-0750-2

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