Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway

BACKGROUND: To investigate the role of P16 (INK4a)-extracellular signal related kinase 1/2 (ERK1/2) signaling pathway in cisplatin (DDP) resistance induced by multidrug resistance protein 1 (MDR1), also known as P-glycoprotein (P-gp), in cervical adenocarcinoma. METHODS: A human DDP-resistant HeLa c...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Yun, Liang, Mei-rong, Liu, Cheng-cheng, Wang, Ya-nan, Zeng, Yang, Zhou, Jun, Zhu, Hui-ting, Wang, Qin, Zou, Yang, Zeng, Si-yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612198/
https://www.ncbi.nlm.nih.gov/pubmed/31312250
http://dx.doi.org/10.1186/s13008-019-0048-6

Ejemplares similares

Ejemplares similares