Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness

BACKGROUND: Follicle depletion is one of the causes of premature ovarian failure (POF) and primary ovarian insufficiency (POI). Hence, maintenance of a certain number of female germline stem cells (FGSCs) is optimal to produce oocytes and replenish the primordial follicle pool. The mechanism that re...

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Detalles Bibliográficos
Autores principales: Jiang, Yu, Zhu, Dantian, Liu, Wenfeng, Qin, Qiushi, Fang, Zhi, Pan, Zezheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612207/
https://www.ncbi.nlm.nih.gov/pubmed/31277696
http://dx.doi.org/10.1186/s13287-019-1299-5

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