Efficacy of humanized single large doses of caspofungin on the lethality and fungal tissue burden in a deeply neutropenic murine model against Candida albicans and Candida dubliniensis

BACKGROUND: Echinocandins are the first-line therapy for treatment of invasive Candida infections, but the mortality rate remains high, calling for novel strategies. Giving single larger echinocandin doses infrequently is an alternative regimen. Our aim was to test this novel approach in a neutropen...

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Detalles Bibliográficos
Autores principales: Prépost, Eszter, Tóth, Zoltán, Perlin, David S, Gesztelyi, Rudolf, Kardos, Gábor, Kovács, Renátó, Nagy, Fruzsina, Forgács, Lajos, Majoros, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612285/
https://www.ncbi.nlm.nih.gov/pubmed/31303773
http://dx.doi.org/10.2147/IDR.S198764

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