Cargando…

Acute kidney injury after cardiac surgery: prevalence, impact and management challenges

Acute kidney injury (AKI) is a major medical problem that is of particular concern after cardiac surgery. Perioperative AKI is independently associated with an increase in short-term morbidity, costs of treatment, and long-term mortality. In this review, we explore the definition of cardiac surgery-...

Descripción completa

Detalles Bibliográficos
Autores principales: Vives, M, Hernandez, A, Parramon, F, Estanyol, N, Pardina, B, Muñoz, A, Alvarez, P, Hernandez, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612286/
https://www.ncbi.nlm.nih.gov/pubmed/31303781
http://dx.doi.org/10.2147/IJNRD.S167477
Descripción
Sumario:Acute kidney injury (AKI) is a major medical problem that is of particular concern after cardiac surgery. Perioperative AKI is independently associated with an increase in short-term morbidity, costs of treatment, and long-term mortality. In this review, we explore the definition of cardiac surgery-associated acute kidney injury (CSA-AKI) and identify diverse mechanisms and risk factors contributing to the renal insult. Current theories of the pathophysiology of CSA-AKI and description of its clinical course will be addressed in this review. Data on the most promising renal protective strategies in cardiac surgery, from well-designed studies, will be scrutinized. Furthermore, diagnostic tools such as novel biomarkers of AKI and their potential utility will be discussed.