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Acute kidney injury after cardiac surgery: prevalence, impact and management challenges
Acute kidney injury (AKI) is a major medical problem that is of particular concern after cardiac surgery. Perioperative AKI is independently associated with an increase in short-term morbidity, costs of treatment, and long-term mortality. In this review, we explore the definition of cardiac surgery-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612286/ https://www.ncbi.nlm.nih.gov/pubmed/31303781 http://dx.doi.org/10.2147/IJNRD.S167477 |
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author | Vives, M Hernandez, A Parramon, F Estanyol, N Pardina, B Muñoz, A Alvarez, P Hernandez, C |
author_facet | Vives, M Hernandez, A Parramon, F Estanyol, N Pardina, B Muñoz, A Alvarez, P Hernandez, C |
author_sort | Vives, M |
collection | PubMed |
description | Acute kidney injury (AKI) is a major medical problem that is of particular concern after cardiac surgery. Perioperative AKI is independently associated with an increase in short-term morbidity, costs of treatment, and long-term mortality. In this review, we explore the definition of cardiac surgery-associated acute kidney injury (CSA-AKI) and identify diverse mechanisms and risk factors contributing to the renal insult. Current theories of the pathophysiology of CSA-AKI and description of its clinical course will be addressed in this review. Data on the most promising renal protective strategies in cardiac surgery, from well-designed studies, will be scrutinized. Furthermore, diagnostic tools such as novel biomarkers of AKI and their potential utility will be discussed. |
format | Online Article Text |
id | pubmed-6612286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-66122862019-07-14 Acute kidney injury after cardiac surgery: prevalence, impact and management challenges Vives, M Hernandez, A Parramon, F Estanyol, N Pardina, B Muñoz, A Alvarez, P Hernandez, C Int J Nephrol Renovasc Dis Review Acute kidney injury (AKI) is a major medical problem that is of particular concern after cardiac surgery. Perioperative AKI is independently associated with an increase in short-term morbidity, costs of treatment, and long-term mortality. In this review, we explore the definition of cardiac surgery-associated acute kidney injury (CSA-AKI) and identify diverse mechanisms and risk factors contributing to the renal insult. Current theories of the pathophysiology of CSA-AKI and description of its clinical course will be addressed in this review. Data on the most promising renal protective strategies in cardiac surgery, from well-designed studies, will be scrutinized. Furthermore, diagnostic tools such as novel biomarkers of AKI and their potential utility will be discussed. Dove 2019-07-02 /pmc/articles/PMC6612286/ /pubmed/31303781 http://dx.doi.org/10.2147/IJNRD.S167477 Text en © 2019 Vives et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Vives, M Hernandez, A Parramon, F Estanyol, N Pardina, B Muñoz, A Alvarez, P Hernandez, C Acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
title | Acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
title_full | Acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
title_fullStr | Acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
title_full_unstemmed | Acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
title_short | Acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
title_sort | acute kidney injury after cardiac surgery: prevalence, impact and management challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612286/ https://www.ncbi.nlm.nih.gov/pubmed/31303781 http://dx.doi.org/10.2147/IJNRD.S167477 |
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