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House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though inte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612401/ https://www.ncbi.nlm.nih.gov/pubmed/31341897 http://dx.doi.org/10.1155/2019/3794876 |
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author | Marquez, Aurélie Ulivieri, Tristan Benoit, Etienne Kodjo, Angeli Lattard, Virginie |
author_facet | Marquez, Aurélie Ulivieri, Tristan Benoit, Etienne Kodjo, Angeli Lattard, Virginie |
author_sort | Marquez, Aurélie |
collection | PubMed |
description | Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though interaction with urine-contaminated environment. Many wildlife species living close to cattle, especially commensal rodents may play a role in the transmission of leptospires. Because little is known on the epidemiology of nonmaintenance Leptospira serovars, appropriate management is still limited. On a French farm where human and cattle leptospirosis were detected, the transmission cycle was explored to propose appropriate mitigation measures. For that, commensal rodents present on the farm were trapped and their leptospires carriage was studied by molecular methods. Trapped mice were shown to carry two pathogenic Leptospira species (L. interrogans and L. kirschneri). Since these 2 serogroups were simultaneously detected in the trapped mice and in the cows of this farm, we suspected an initial Leptospira transmission from mice to cows requiring an effective management of mice on this farm. Because resistance to anticoagulant rodenticides due to Vkorc1 mutations has been largely described in rodents and first-generation anticoagulant rodenticides seemed to be inefficient in controlling mice on this farm, susceptibility of these mice to anticoagulants has been characterized by Vkorc1 sequencing. 50% of the trapped mice carried mutations in the Vkorc1 gene leading to severe resistance to first-generation anticoagulants. The management of such mice that are a real sanitary threat can be achieved only by using the most toxic second-generation anticoagulants or nonanticoagulant solutions. |
format | Online Article Text |
id | pubmed-6612401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66124012019-07-24 House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management Marquez, Aurélie Ulivieri, Tristan Benoit, Etienne Kodjo, Angeli Lattard, Virginie Biomed Res Int Research Article Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though interaction with urine-contaminated environment. Many wildlife species living close to cattle, especially commensal rodents may play a role in the transmission of leptospires. Because little is known on the epidemiology of nonmaintenance Leptospira serovars, appropriate management is still limited. On a French farm where human and cattle leptospirosis were detected, the transmission cycle was explored to propose appropriate mitigation measures. For that, commensal rodents present on the farm were trapped and their leptospires carriage was studied by molecular methods. Trapped mice were shown to carry two pathogenic Leptospira species (L. interrogans and L. kirschneri). Since these 2 serogroups were simultaneously detected in the trapped mice and in the cows of this farm, we suspected an initial Leptospira transmission from mice to cows requiring an effective management of mice on this farm. Because resistance to anticoagulant rodenticides due to Vkorc1 mutations has been largely described in rodents and first-generation anticoagulant rodenticides seemed to be inefficient in controlling mice on this farm, susceptibility of these mice to anticoagulants has been characterized by Vkorc1 sequencing. 50% of the trapped mice carried mutations in the Vkorc1 gene leading to severe resistance to first-generation anticoagulants. The management of such mice that are a real sanitary threat can be achieved only by using the most toxic second-generation anticoagulants or nonanticoagulant solutions. Hindawi 2019-06-23 /pmc/articles/PMC6612401/ /pubmed/31341897 http://dx.doi.org/10.1155/2019/3794876 Text en Copyright © 2019 Aurélie Marquez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Marquez, Aurélie Ulivieri, Tristan Benoit, Etienne Kodjo, Angeli Lattard, Virginie House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management |
title | House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management |
title_full | House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management |
title_fullStr | House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management |
title_full_unstemmed | House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management |
title_short | House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management |
title_sort | house mice as a real sanitary threat of human and animal leptospirosis: proposal for integrated management |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612401/ https://www.ncbi.nlm.nih.gov/pubmed/31341897 http://dx.doi.org/10.1155/2019/3794876 |
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