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House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management

Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though inte...

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Autores principales: Marquez, Aurélie, Ulivieri, Tristan, Benoit, Etienne, Kodjo, Angeli, Lattard, Virginie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612401/
https://www.ncbi.nlm.nih.gov/pubmed/31341897
http://dx.doi.org/10.1155/2019/3794876
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author Marquez, Aurélie
Ulivieri, Tristan
Benoit, Etienne
Kodjo, Angeli
Lattard, Virginie
author_facet Marquez, Aurélie
Ulivieri, Tristan
Benoit, Etienne
Kodjo, Angeli
Lattard, Virginie
author_sort Marquez, Aurélie
collection PubMed
description Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though interaction with urine-contaminated environment. Many wildlife species living close to cattle, especially commensal rodents may play a role in the transmission of leptospires. Because little is known on the epidemiology of nonmaintenance Leptospira serovars, appropriate management is still limited. On a French farm where human and cattle leptospirosis were detected, the transmission cycle was explored to propose appropriate mitigation measures. For that, commensal rodents present on the farm were trapped and their leptospires carriage was studied by molecular methods. Trapped mice were shown to carry two pathogenic Leptospira species (L. interrogans and L. kirschneri). Since these 2 serogroups were simultaneously detected in the trapped mice and in the cows of this farm, we suspected an initial Leptospira transmission from mice to cows requiring an effective management of mice on this farm. Because resistance to anticoagulant rodenticides due to Vkorc1 mutations has been largely described in rodents and first-generation anticoagulant rodenticides seemed to be inefficient in controlling mice on this farm, susceptibility of these mice to anticoagulants has been characterized by Vkorc1 sequencing. 50% of the trapped mice carried mutations in the Vkorc1 gene leading to severe resistance to first-generation anticoagulants. The management of such mice that are a real sanitary threat can be achieved only by using the most toxic second-generation anticoagulants or nonanticoagulant solutions.
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spelling pubmed-66124012019-07-24 House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management Marquez, Aurélie Ulivieri, Tristan Benoit, Etienne Kodjo, Angeli Lattard, Virginie Biomed Res Int Research Article Leptospirosis is a reemerging zoonosis and ranges in severity from benign to sometimes fatal. In cattle, infection may be responsible for abortion and infertility cases causing economic losses. Humans may be contaminated through direct contact with urine of infected animals or indirectly though interaction with urine-contaminated environment. Many wildlife species living close to cattle, especially commensal rodents may play a role in the transmission of leptospires. Because little is known on the epidemiology of nonmaintenance Leptospira serovars, appropriate management is still limited. On a French farm where human and cattle leptospirosis were detected, the transmission cycle was explored to propose appropriate mitigation measures. For that, commensal rodents present on the farm were trapped and their leptospires carriage was studied by molecular methods. Trapped mice were shown to carry two pathogenic Leptospira species (L. interrogans and L. kirschneri). Since these 2 serogroups were simultaneously detected in the trapped mice and in the cows of this farm, we suspected an initial Leptospira transmission from mice to cows requiring an effective management of mice on this farm. Because resistance to anticoagulant rodenticides due to Vkorc1 mutations has been largely described in rodents and first-generation anticoagulant rodenticides seemed to be inefficient in controlling mice on this farm, susceptibility of these mice to anticoagulants has been characterized by Vkorc1 sequencing. 50% of the trapped mice carried mutations in the Vkorc1 gene leading to severe resistance to first-generation anticoagulants. The management of such mice that are a real sanitary threat can be achieved only by using the most toxic second-generation anticoagulants or nonanticoagulant solutions. Hindawi 2019-06-23 /pmc/articles/PMC6612401/ /pubmed/31341897 http://dx.doi.org/10.1155/2019/3794876 Text en Copyright © 2019 Aurélie Marquez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Marquez, Aurélie
Ulivieri, Tristan
Benoit, Etienne
Kodjo, Angeli
Lattard, Virginie
House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
title House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
title_full House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
title_fullStr House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
title_full_unstemmed House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
title_short House Mice as a Real Sanitary Threat of Human and Animal Leptospirosis: Proposal for Integrated Management
title_sort house mice as a real sanitary threat of human and animal leptospirosis: proposal for integrated management
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612401/
https://www.ncbi.nlm.nih.gov/pubmed/31341897
http://dx.doi.org/10.1155/2019/3794876
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