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Enteric peripheral neuroblastoma in a calf

An 11-month-old female Japanese Black calf had showed chronic intestinal symptoms. A large mass surrounding the colon wall that was continuous with the colon submucosa was surgically removed. After recurrence and euthanasia, a large mass in the colon region and metastatic masses in the omentum, live...

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Detalles Bibliográficos
Autores principales: SAKAI, Yusuke, HIYAMA, Masato, KAGIMOTO, Saya, MITSUI, Yuki, IMAIUMI, Miko, OKAYAMA, Takeshi, HARADONO, Kaori, SAKURAI, Masashi, MORIMOTO, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612498/
https://www.ncbi.nlm.nih.gov/pubmed/30971632
http://dx.doi.org/10.1292/jvms.18-0450
Descripción
Sumario:An 11-month-old female Japanese Black calf had showed chronic intestinal symptoms. A large mass surrounding the colon wall that was continuous with the colon submucosa was surgically removed. After recurrence and euthanasia, a large mass in the colon region and metastatic masses in the omentum, liver, and lung were revealed at necropsy. Pleomorphic small cells proliferated in the mass and muscular layer of the colon. The cells were positively stained with anti-doublecortin (DCX), PGP9.5, nestin, and neuron specific enolase (NSE). Thus, the diagnosis of peripheral neuroblastoma was made. This is the first report of enteric peripheral neuroblastoma in animals. Also, clear DCX staining signal suggested usefulness of DCX immunohistochemistry to differentiate the neuroblastoma from other small cell tumors in cattle.