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Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats
Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. A...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612506/ https://www.ncbi.nlm.nih.gov/pubmed/30982807 http://dx.doi.org/10.1292/jvms.19-0064 |
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author | HAMADA, Mizuki IHARA, Tsubasa FURUSE, Mitsuhiro |
author_facet | HAMADA, Mizuki IHARA, Tsubasa FURUSE, Mitsuhiro |
author_sort | HAMADA, Mizuki |
collection | PubMed |
description | Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. At the neonatal stage, free amino acids in milk are important nutrients because they act as immediate nutrients for offspring and may affect later health and behavior of the offspring. Therefore, the present study aimed to investigate free amino acid concentrations in milk and the relationships between free amino acid concentrations in milk and plasma in WIS and WKY rats. The concentrations of ten of the determined free amino acids in milk were significantly higher, but only L-methionine was significantly lower, in WKY rats. Six free amino acids had significantly higher concentrations in colostrum and two free amino acids had higher concentrations in matured milk. Free amino acid concentrations in plasma changed by both genetic background and lactation stage; however, the patterns of change in most free amino acid concentrations except for taurine in plasma were similar between WIS and WKY rats. The transport ratio of free amino acids from plasma to milk was not similar among the free amino acids tested, and each free amino acid was influenced by the genetic background and/or the type of milk. |
format | Online Article Text |
id | pubmed-6612506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-66125062019-07-12 Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats HAMADA, Mizuki IHARA, Tsubasa FURUSE, Mitsuhiro J Vet Med Sci Physiology Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. At the neonatal stage, free amino acids in milk are important nutrients because they act as immediate nutrients for offspring and may affect later health and behavior of the offspring. Therefore, the present study aimed to investigate free amino acid concentrations in milk and the relationships between free amino acid concentrations in milk and plasma in WIS and WKY rats. The concentrations of ten of the determined free amino acids in milk were significantly higher, but only L-methionine was significantly lower, in WKY rats. Six free amino acids had significantly higher concentrations in colostrum and two free amino acids had higher concentrations in matured milk. Free amino acid concentrations in plasma changed by both genetic background and lactation stage; however, the patterns of change in most free amino acid concentrations except for taurine in plasma were similar between WIS and WKY rats. The transport ratio of free amino acids from plasma to milk was not similar among the free amino acids tested, and each free amino acid was influenced by the genetic background and/or the type of milk. The Japanese Society of Veterinary Science 2019-04-15 2019-06 /pmc/articles/PMC6612506/ /pubmed/30982807 http://dx.doi.org/10.1292/jvms.19-0064 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Physiology HAMADA, Mizuki IHARA, Tsubasa FURUSE, Mitsuhiro Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats |
title | Differences in free amino acid concentrations in milk between Wistar and
Wistar Kyoto rats |
title_full | Differences in free amino acid concentrations in milk between Wistar and
Wistar Kyoto rats |
title_fullStr | Differences in free amino acid concentrations in milk between Wistar and
Wistar Kyoto rats |
title_full_unstemmed | Differences in free amino acid concentrations in milk between Wistar and
Wistar Kyoto rats |
title_short | Differences in free amino acid concentrations in milk between Wistar and
Wistar Kyoto rats |
title_sort | differences in free amino acid concentrations in milk between wistar and
wistar kyoto rats |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612506/ https://www.ncbi.nlm.nih.gov/pubmed/30982807 http://dx.doi.org/10.1292/jvms.19-0064 |
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