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Are skin senescence and immunosenescence linked within individuals?

With advancing age, many organs exhibit functional deterioration. The age‐associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. While senescent cells are found in several different organ systems, it is not known whether they arise independent...

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Autores principales: Waaijer, Mariëtte E. C., Goldeck, David, Gunn, David A., van Heemst, Diana, Westendorp, Rudi G. J., Pawelec, Graham, Maier, Andrea B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612632/
https://www.ncbi.nlm.nih.gov/pubmed/31062498
http://dx.doi.org/10.1111/acel.12956
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author Waaijer, Mariëtte E. C.
Goldeck, David
Gunn, David A.
van Heemst, Diana
Westendorp, Rudi G. J.
Pawelec, Graham
Maier, Andrea B.
author_facet Waaijer, Mariëtte E. C.
Goldeck, David
Gunn, David A.
van Heemst, Diana
Westendorp, Rudi G. J.
Pawelec, Graham
Maier, Andrea B.
author_sort Waaijer, Mariëtte E. C.
collection PubMed
description With advancing age, many organs exhibit functional deterioration. The age‐associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. While senescent cells are found in several different organ systems, it is not known whether they arise independently in each organ system or whether their prevalence within an individual reflects that individual's intrinsic aging process. To address this question, we studied senescence in two different organ systems in humans, namely skin and T cells in 80 middle‐aged and older individuals from the Leiden Longevity Study. Epidermal p16INK4a positivity was associated with neither CD4(+) nor CD8(+) T‐cell immunosenescence phenotype composites (i.e., end‐stage differentiated/senescent T cells, including CD45RA(+)CCR7(‐)CD28(‐)CD27(‐)CD57(+)KLRG1(+) T cells). Dermal p16INK4a positivity was significantly associated with the CD4(+), but not with the CD8(+) immunosenescence composite. We therefore conclude that there is limited evidence for a link between skin senescence and immunosenescence within individuals.
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spelling pubmed-66126322019-08-01 Are skin senescence and immunosenescence linked within individuals? Waaijer, Mariëtte E. C. Goldeck, David Gunn, David A. van Heemst, Diana Westendorp, Rudi G. J. Pawelec, Graham Maier, Andrea B. Aging Cell Short Take With advancing age, many organs exhibit functional deterioration. The age‐associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. While senescent cells are found in several different organ systems, it is not known whether they arise independently in each organ system or whether their prevalence within an individual reflects that individual's intrinsic aging process. To address this question, we studied senescence in two different organ systems in humans, namely skin and T cells in 80 middle‐aged and older individuals from the Leiden Longevity Study. Epidermal p16INK4a positivity was associated with neither CD4(+) nor CD8(+) T‐cell immunosenescence phenotype composites (i.e., end‐stage differentiated/senescent T cells, including CD45RA(+)CCR7(‐)CD28(‐)CD27(‐)CD57(+)KLRG1(+) T cells). Dermal p16INK4a positivity was significantly associated with the CD4(+), but not with the CD8(+) immunosenescence composite. We therefore conclude that there is limited evidence for a link between skin senescence and immunosenescence within individuals. John Wiley and Sons Inc. 2019-05-06 2019-08 /pmc/articles/PMC6612632/ /pubmed/31062498 http://dx.doi.org/10.1111/acel.12956 Text en © 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Take
Waaijer, Mariëtte E. C.
Goldeck, David
Gunn, David A.
van Heemst, Diana
Westendorp, Rudi G. J.
Pawelec, Graham
Maier, Andrea B.
Are skin senescence and immunosenescence linked within individuals?
title Are skin senescence and immunosenescence linked within individuals?
title_full Are skin senescence and immunosenescence linked within individuals?
title_fullStr Are skin senescence and immunosenescence linked within individuals?
title_full_unstemmed Are skin senescence and immunosenescence linked within individuals?
title_short Are skin senescence and immunosenescence linked within individuals?
title_sort are skin senescence and immunosenescence linked within individuals?
topic Short Take
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612632/
https://www.ncbi.nlm.nih.gov/pubmed/31062498
http://dx.doi.org/10.1111/acel.12956
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