Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

Hutchinson–Gilford progeria syndrome (HGPS) is characterized by accelerated senescence due to a de novo mutation in the LMNA gene. The mutation produces an abnormal lamin A protein called progerin that lacks the splice site necessary to remove a farnesylated domain. Subsequently, progerin accumulate...

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Detalles Bibliográficos
Autores principales: Li, Yanhui, Zhou, Gang, Bruno, Ivone G., Zhang, Ning, Sho, Sei, Tedone, Enzo, Lai, Tsung‐Po, Cooke, John P., Shay, Jerry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612639/
https://www.ncbi.nlm.nih.gov/pubmed/31152494
http://dx.doi.org/10.1111/acel.12979

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