α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1

α‐Synuclein (aSyn) toxicity is associated with cell cycle alterations, activation of DNA damage responses (DDR), and deregulation of autophagy. However, the relationships between these phenomena remain largely unknown. Here, we demonstrate that in a yeast model of aSyn toxicity and aging, aSyn expre...

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Detalles Bibliográficos
Autores principales: Sampaio‐Marques, Belém, Guedes, Ana, Vasilevskiy, Igor, Gonçalves, Susana, Outeiro, Tiago F., Winderickx, Joris, Burhans, William C., Ludovico, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612645/
https://www.ncbi.nlm.nih.gov/pubmed/30977294
http://dx.doi.org/10.1111/acel.12922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612645/
https://www.ncbi.nlm.nih.gov/pubmed/30977294
http://dx.doi.org/10.1111/acel.12922

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