Cargando…

CpG‐related SNPs in the MS4A region have a dose‐dependent effect on risk of late–onset Alzheimer disease

CpG‐related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome‐wide association study using a sliding‐window approach to measure the combined effects...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Yiyi, Jun, Gyungah R., Chung, Jaeyoon, Zhang, Xiaoling, Kunkle, Brian W., Naj, Adam C., White, Charles C., Bennett, David A, De Jager, Philip L., Mayeux, Richard, Haines, Jonathan L., Pericak‐Vance, Margaret A., Schellenberg, Gerard D., Farrer, Lindsay A., Lunetta, Kathryn L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612647/ https://www.ncbi.nlm.nih.gov/pubmed/31144443 http://dx.doi.org/10.1111/acel.12964

Ejemplares similares

One for all and all for One: Improving replication of genetic studies through network diffusion
por: Lancour, Daniel, et al.
Publicado: (2018)

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
por: Chung, Jaeyoon, et al.
Publicado: (2018)

Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease
por: Zhang, Xiaoling, et al.
Publicado: (2021)

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease
por: Jun, Gyungah R., et al.
Publicado: (2022)

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease
por: Lancour, Daniel, et al.
Publicado: (2020)

Performance of random forest when SNPs are in linkage disequilibrium
por: Meng, Yan A, et al.
Publicado: (2009)

Different Methylation of CpG-SNPs in Behcet's Disease
por: Huang, Yang, et al.
Publicado: (2019)

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry
por: Patel, Devanshi, et al.
Publicado: (2019)

Comparison of methods for multivariate gene-based association tests for complex diseases using common variants
por: Chung, Jaeyoon, et al.
Publicado: (2019)

An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
por: Jin, Bowen, et al.
Publicado: (2022)

Corrigendum: An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease–related patterns
por: Jin, Bowen, et al.
Publicado: (2022)

Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
por: Maldonado, Mariângela B. C., et al.
Publicado: (2019)

Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease
por: Xue, Diane, et al.
Publicado: (2021)

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease
por: Panitch, Rebecca, et al.
Publicado: (2021)

Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue
por: Patel, Devanshi, et al.
Publicado: (2021)

Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease
por: Chen, Xiaomin, et al.
Publicado: (2016)

Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease
por: Beecham, Gary W., et al.
Publicado: (2018)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs
por: Zhou, Dan, et al.
Publicado: (2015)

Detection and analysis of CpG sites with multimodal DNA methylation level distributions and their relationships with SNPs
por: Hu, Ke, et al.
Publicado: (2018)

Identification of novel functional CpG-SNPs associated with Type 2 diabetes and birth weight
por: Liu, Rui-Ke, et al.
Publicado: (2021)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
por: Dayeh, T. A., et al.
Publicado: (2013)

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
por: Reitz, C, et al.
Publicado: (2013)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

Progranulin mutations in clinical and neuropathological Alzheimer's disease
por: Vardarajan, Badri N., et al.
Publicado: (2022)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
por: Grandi, Fiorella C., et al.
Publicado: (2015)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale
por: Barrera, Víctor, et al.
Publicado: (2012)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

SNPs in Multi-Species Conserved Sequences (MCS) as useful markers in association studies: a practical approach
por: McCauley, Jacob L, et al.
Publicado: (2007)

Antibody targeted CpG for the immunotherapy of solid tumors
por: Epstein, Alan L, et al.
Publicado: (2015)

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
por: Cukier, Holly N., et al.
Publicado: (2016)

Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants
por: Patel, Devanshi, et al.
Publicado: (2021)

Inhaled CpG increases survival and synergizes with checkpoint inhibition in lymphangioleiomyomatosis
por: Amosu, Mayowa M, et al.
Publicado: (2023)

Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease
por: Kohli, Martin A., et al.
Publicado: (2016)

Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease
por: Vardarajan, Badri N., et al.
Publicado: (2018)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p92lsfps804ed2sq8jc6tul3sb