Targeted therapy and personalized medicine in gastrointestinal stromal tumors: drug resistance, mechanisms, and treatment strategies

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Since the discovery that the KIT and PDGFRA receptor tyrosine kinases are the primary oncogenic drivers in the vast majority of GISTs, targeted therapy with tyrosine kinase inhibitors has...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, George Z, Raut, Chandrajit P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612765/
https://www.ncbi.nlm.nih.gov/pubmed/31308690
http://dx.doi.org/10.2147/OTT.S180763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612765/
https://www.ncbi.nlm.nih.gov/pubmed/31308690
http://dx.doi.org/10.2147/OTT.S180763

Ejemplares similares