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Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia

A reduction of GABAergic markers in postmortem tissue is consistently found in schizophrenia. Importantly, these alterations in GABAergic neurons are not global, which means they are more prevalent among distinct subclasses of interneurons, including those that express the calcium binding protein pa...

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Autores principales: Hayashida, Maiko, Miyaoka, Tsuyoshi, Tsuchie, Keiko, Araki, Tomoko, Izuhara, Muneto, Miura, Shoko, Kanayama, Misako, Ohtsuki, Koji, Nagahama, Michiharu, Azis, Ilhamuddin Abdul, Abdullah, Rostia Arianna, Jaya, Muhammad Alim, Arauchi, Ryosuke, Hashioka, Sadayuki, Wake, Rei, Tsumori, Toshiko, Horiguchi, Jun, Oh-Nishi, Arata, Inagaki, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612903/
https://www.ncbi.nlm.nih.gov/pubmed/31321330
http://dx.doi.org/10.1016/j.heliyon.2019.e02037
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author Hayashida, Maiko
Miyaoka, Tsuyoshi
Tsuchie, Keiko
Araki, Tomoko
Izuhara, Muneto
Miura, Shoko
Kanayama, Misako
Ohtsuki, Koji
Nagahama, Michiharu
Azis, Ilhamuddin Abdul
Abdullah, Rostia Arianna
Jaya, Muhammad Alim
Arauchi, Ryosuke
Hashioka, Sadayuki
Wake, Rei
Tsumori, Toshiko
Horiguchi, Jun
Oh-Nishi, Arata
Inagaki, Masatoshi
author_facet Hayashida, Maiko
Miyaoka, Tsuyoshi
Tsuchie, Keiko
Araki, Tomoko
Izuhara, Muneto
Miura, Shoko
Kanayama, Misako
Ohtsuki, Koji
Nagahama, Michiharu
Azis, Ilhamuddin Abdul
Abdullah, Rostia Arianna
Jaya, Muhammad Alim
Arauchi, Ryosuke
Hashioka, Sadayuki
Wake, Rei
Tsumori, Toshiko
Horiguchi, Jun
Oh-Nishi, Arata
Inagaki, Masatoshi
author_sort Hayashida, Maiko
collection PubMed
description A reduction of GABAergic markers in postmortem tissue is consistently found in schizophrenia. Importantly, these alterations in GABAergic neurons are not global, which means they are more prevalent among distinct subclasses of interneurons, including those that express the calcium binding protein parvalbumin. A decreased expression of parvalbumin in the hippocampus is a consistent observation not only in postmortem human schizophrenia patients, but also in a diverse number of rodent models of the disease. Meanwhile, previously we reported that the congenital hyperbilirubinemia model rats (Gunn rats), which is a mutant of the Wistar strain, showed behavioral abnormalities, for instance, hyperlocomotor activity, deficits of prepulse inhibition, inappropriate social interaction, impaired recognition memory similar with several rodent models of schizophrenia. Several animal studies linked the importance of palvalbumin in relation to abnormal hippocampal activity and schizophrenia-like behavior. Here, we show that parvalbumin positive cell density was significantly lower in the CA1, CA3 and the total hippocampus of Gunn rats (congenital hyperbilirubinemia model rats) compared to Wistar control rats. The correlations between serum UCB levels and loss of PV expression in the hippocampus were also detected. The decreases in the PV-expression in the hippocampus might suggest an association of the behavioral abnormalities as schizophrenia-like behaviors of Gunn rats, compared to the Wistar control rats.
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spelling pubmed-66129032019-07-18 Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia Hayashida, Maiko Miyaoka, Tsuyoshi Tsuchie, Keiko Araki, Tomoko Izuhara, Muneto Miura, Shoko Kanayama, Misako Ohtsuki, Koji Nagahama, Michiharu Azis, Ilhamuddin Abdul Abdullah, Rostia Arianna Jaya, Muhammad Alim Arauchi, Ryosuke Hashioka, Sadayuki Wake, Rei Tsumori, Toshiko Horiguchi, Jun Oh-Nishi, Arata Inagaki, Masatoshi Heliyon Article A reduction of GABAergic markers in postmortem tissue is consistently found in schizophrenia. Importantly, these alterations in GABAergic neurons are not global, which means they are more prevalent among distinct subclasses of interneurons, including those that express the calcium binding protein parvalbumin. A decreased expression of parvalbumin in the hippocampus is a consistent observation not only in postmortem human schizophrenia patients, but also in a diverse number of rodent models of the disease. Meanwhile, previously we reported that the congenital hyperbilirubinemia model rats (Gunn rats), which is a mutant of the Wistar strain, showed behavioral abnormalities, for instance, hyperlocomotor activity, deficits of prepulse inhibition, inappropriate social interaction, impaired recognition memory similar with several rodent models of schizophrenia. Several animal studies linked the importance of palvalbumin in relation to abnormal hippocampal activity and schizophrenia-like behavior. Here, we show that parvalbumin positive cell density was significantly lower in the CA1, CA3 and the total hippocampus of Gunn rats (congenital hyperbilirubinemia model rats) compared to Wistar control rats. The correlations between serum UCB levels and loss of PV expression in the hippocampus were also detected. The decreases in the PV-expression in the hippocampus might suggest an association of the behavioral abnormalities as schizophrenia-like behaviors of Gunn rats, compared to the Wistar control rats. Elsevier 2019-07-05 /pmc/articles/PMC6612903/ /pubmed/31321330 http://dx.doi.org/10.1016/j.heliyon.2019.e02037 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hayashida, Maiko
Miyaoka, Tsuyoshi
Tsuchie, Keiko
Araki, Tomoko
Izuhara, Muneto
Miura, Shoko
Kanayama, Misako
Ohtsuki, Koji
Nagahama, Michiharu
Azis, Ilhamuddin Abdul
Abdullah, Rostia Arianna
Jaya, Muhammad Alim
Arauchi, Ryosuke
Hashioka, Sadayuki
Wake, Rei
Tsumori, Toshiko
Horiguchi, Jun
Oh-Nishi, Arata
Inagaki, Masatoshi
Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia
title Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia
title_full Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia
title_fullStr Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia
title_full_unstemmed Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia
title_short Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia
title_sort parvalbumin-positive gabaergic interneurons deficit in the hippocampus in gunn rats: a possible hyperbilirubinemia-induced animal model of schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612903/
https://www.ncbi.nlm.nih.gov/pubmed/31321330
http://dx.doi.org/10.1016/j.heliyon.2019.e02037
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