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Study Insights into Gastrointestinal Cancer through the Gut Microbiota
The gut microbiome in human is recognized as a “microbial organ” for its roles and contributions in regulating the human homeostasis and metabolism. Gastrointestinal (GI) cancers, especially colorectal cancer (CRC), rank as the most common cancer-related deaths worldwide. Evidences have suggested th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612970/ https://www.ncbi.nlm.nih.gov/pubmed/31341907 http://dx.doi.org/10.1155/2019/8721503 |
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author | Kong, Fanli Cai, Yi |
author_facet | Kong, Fanli Cai, Yi |
author_sort | Kong, Fanli |
collection | PubMed |
description | The gut microbiome in human is recognized as a “microbial organ” for its roles and contributions in regulating the human homeostasis and metabolism. Gastrointestinal (GI) cancers, especially colorectal cancer (CRC), rank as the most common cancer-related deaths worldwide. Evidences have suggested that the disorder of gut microbiota, also named as “dysbiosis,” is related to the development of a variety of diseases such as inflammatory bowel disease (IBD) and the CRC. However, detailed mechanisms between disease and gut microbiota remain largely unknown. This review introduced the correlation between gastrointestinal diseases and the microbiota in human gut from the recent studies, as well as the roles of microbiota in manipulating the CRC and IBDs development, in order to facilitate future studies and to develop novel methods for the precaution, diagnosis, or even cure of gastrointestinal diseases. Additionally, we also elucidated the possibility of probiotics in treatment against CRC. |
format | Online Article Text |
id | pubmed-6612970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66129702019-07-24 Study Insights into Gastrointestinal Cancer through the Gut Microbiota Kong, Fanli Cai, Yi Biomed Res Int Review Article The gut microbiome in human is recognized as a “microbial organ” for its roles and contributions in regulating the human homeostasis and metabolism. Gastrointestinal (GI) cancers, especially colorectal cancer (CRC), rank as the most common cancer-related deaths worldwide. Evidences have suggested that the disorder of gut microbiota, also named as “dysbiosis,” is related to the development of a variety of diseases such as inflammatory bowel disease (IBD) and the CRC. However, detailed mechanisms between disease and gut microbiota remain largely unknown. This review introduced the correlation between gastrointestinal diseases and the microbiota in human gut from the recent studies, as well as the roles of microbiota in manipulating the CRC and IBDs development, in order to facilitate future studies and to develop novel methods for the precaution, diagnosis, or even cure of gastrointestinal diseases. Additionally, we also elucidated the possibility of probiotics in treatment against CRC. Hindawi 2019-06-24 /pmc/articles/PMC6612970/ /pubmed/31341907 http://dx.doi.org/10.1155/2019/8721503 Text en Copyright © 2019 Fanli Kong and Yi Cai. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kong, Fanli Cai, Yi Study Insights into Gastrointestinal Cancer through the Gut Microbiota |
title | Study Insights into Gastrointestinal Cancer through the Gut Microbiota |
title_full | Study Insights into Gastrointestinal Cancer through the Gut Microbiota |
title_fullStr | Study Insights into Gastrointestinal Cancer through the Gut Microbiota |
title_full_unstemmed | Study Insights into Gastrointestinal Cancer through the Gut Microbiota |
title_short | Study Insights into Gastrointestinal Cancer through the Gut Microbiota |
title_sort | study insights into gastrointestinal cancer through the gut microbiota |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612970/ https://www.ncbi.nlm.nih.gov/pubmed/31341907 http://dx.doi.org/10.1155/2019/8721503 |
work_keys_str_mv | AT kongfanli studyinsightsintogastrointestinalcancerthroughthegutmicrobiota AT caiyi studyinsightsintogastrointestinalcancerthroughthegutmicrobiota |