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Physiological function of seminal vesicle secretions on male fecundity
BACKGROUND: A mixture of spermatozoa and accessory gland secretions (from seminal vesicles, prostates, and coagulating glands) is ejaculated into the female reproductive tract at copulation. However, the physiological function of accessory glands on male fecundity remains unclear. METHODS: Publicati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613004/ https://www.ncbi.nlm.nih.gov/pubmed/31312102 http://dx.doi.org/10.1002/rmb2.12282 |
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author | Noda, Taichi Ikawa, Masahito |
author_facet | Noda, Taichi Ikawa, Masahito |
author_sort | Noda, Taichi |
collection | PubMed |
description | BACKGROUND: A mixture of spermatozoa and accessory gland secretions (from seminal vesicles, prostates, and coagulating glands) is ejaculated into the female reproductive tract at copulation. However, the physiological function of accessory glands on male fecundity remains unclear. METHODS: Publications regarding the physiological functions of male accessory glands were summarized. MAIN FINDINGS (RESULTS): The functions of accessory glands have been studied using male rodents surgically removed coagulating glands (CG), prostates (PR), or seminal vesicles (SV). CG‐removed males are fertile or subfertile, while the fecundity of PR‐removed males is controversial. SV‐removed males show copulatory plug defects, leading to fewer sperm in the uterus and severe subfertility. TGM4, SVS2, and PATE4 were identified as essential factors for copulatory plug formation. When the sufficient number of epididymal spermatozoa was artificially injected into a uterus (AI method), they could efficiently fertilize oocytes, implicating that accessory gland secretions are not essential. Seminal vesicle secretions (SVSs) improved fertilization rates only when low numbers of spermatozoa were used for AI. The changes of uterine environment by SVSs could not improve the pregnancy rate. CONCLUSION: Accessory gland factors are critical for copulatory plug formation and support sperm fertilizing ability. |
format | Online Article Text |
id | pubmed-6613004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66130042019-07-16 Physiological function of seminal vesicle secretions on male fecundity Noda, Taichi Ikawa, Masahito Reprod Med Biol Mini Reviews BACKGROUND: A mixture of spermatozoa and accessory gland secretions (from seminal vesicles, prostates, and coagulating glands) is ejaculated into the female reproductive tract at copulation. However, the physiological function of accessory glands on male fecundity remains unclear. METHODS: Publications regarding the physiological functions of male accessory glands were summarized. MAIN FINDINGS (RESULTS): The functions of accessory glands have been studied using male rodents surgically removed coagulating glands (CG), prostates (PR), or seminal vesicles (SV). CG‐removed males are fertile or subfertile, while the fecundity of PR‐removed males is controversial. SV‐removed males show copulatory plug defects, leading to fewer sperm in the uterus and severe subfertility. TGM4, SVS2, and PATE4 were identified as essential factors for copulatory plug formation. When the sufficient number of epididymal spermatozoa was artificially injected into a uterus (AI method), they could efficiently fertilize oocytes, implicating that accessory gland secretions are not essential. Seminal vesicle secretions (SVSs) improved fertilization rates only when low numbers of spermatozoa were used for AI. The changes of uterine environment by SVSs could not improve the pregnancy rate. CONCLUSION: Accessory gland factors are critical for copulatory plug formation and support sperm fertilizing ability. John Wiley and Sons Inc. 2019-06-17 /pmc/articles/PMC6613004/ /pubmed/31312102 http://dx.doi.org/10.1002/rmb2.12282 Text en © 2019 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Mini Reviews Noda, Taichi Ikawa, Masahito Physiological function of seminal vesicle secretions on male fecundity |
title | Physiological function of seminal vesicle secretions on male fecundity |
title_full | Physiological function of seminal vesicle secretions on male fecundity |
title_fullStr | Physiological function of seminal vesicle secretions on male fecundity |
title_full_unstemmed | Physiological function of seminal vesicle secretions on male fecundity |
title_short | Physiological function of seminal vesicle secretions on male fecundity |
title_sort | physiological function of seminal vesicle secretions on male fecundity |
topic | Mini Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613004/ https://www.ncbi.nlm.nih.gov/pubmed/31312102 http://dx.doi.org/10.1002/rmb2.12282 |
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