Cargando…

VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study

AIM: This study investigated the associations among early pregnancy vitamin D concentrations, seasonality, and vitamin D metabolic gene variants and how these variables related alone and in interaction with the risk of gestational diabetes mellitus (GDM). METHODS: Research participants were women fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Beibei, Huang, Kun, Yan, Shuangqin, Hao, Jiahu, Zhu, Peng, Chen, Yao, Ye, Aoxing, Tao, Fangbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613005/
https://www.ncbi.nlm.nih.gov/pubmed/31341914
http://dx.doi.org/10.1155/2019/8313901
_version_ 1783432980117585920
author Zhu, Beibei
Huang, Kun
Yan, Shuangqin
Hao, Jiahu
Zhu, Peng
Chen, Yao
Ye, Aoxing
Tao, Fangbiao
author_facet Zhu, Beibei
Huang, Kun
Yan, Shuangqin
Hao, Jiahu
Zhu, Peng
Chen, Yao
Ye, Aoxing
Tao, Fangbiao
author_sort Zhu, Beibei
collection PubMed
description AIM: This study investigated the associations among early pregnancy vitamin D concentrations, seasonality, and vitamin D metabolic gene variants and how these variables related alone and in interaction with the risk of gestational diabetes mellitus (GDM). METHODS: Research participants were women from the Ma'anshan birth cohort study in China. The overall study included 3110 women to explore the association between early pregnancy vitamin D concentrations and the risk of GDM. In the current analysis, a nested case-control study of 274 GDM cases and 380 controls was conducted to investigate seven vitamin D metabolic gene variants and the risk of GDM. Vitamin D concentrations were measured by radioimmunoassay. Genotypes were determined by improved multiple ligase detection reaction. Interactions between genetic variants and vitamin D as predictors of the risk of GDM were evaluated by a pair-wise analysis under a multiplicative interaction model. RESULTS: Vitamin D concentrations were not significantly associated with the risk of GDM (OR = 0.79, 95% CI = 0.55-1.13) after adjusting for seasonality. Fall-winter conceptions had a 37% decreased risk of GDM compared with spring-summer conceptions (OR = 0.63, 95% CI = 0.49-0.81), independent of vitamin D concentrations. Two VDR gene variants rs1544410 (OR = 2.03, 95% CI = 1.17-3.51 for CT versus CC) and rs731236 (OR = 2.42, 95% CI = 1.29-4.55 for GA versus AA) were significantly associated with the risk of GDM. No interactions among genetic variants and vitamin D concentrations were detected. CONCLUSION: Early pregnancy vitamin D insufficiency or deficiency was not significantly associated with the risk of GDM. The results of this study emphasize the importance of genetic variants in VDR and conception season as factors that affect the risk of GDM.
format Online
Article
Text
id pubmed-6613005
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-66130052019-07-24 VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study Zhu, Beibei Huang, Kun Yan, Shuangqin Hao, Jiahu Zhu, Peng Chen, Yao Ye, Aoxing Tao, Fangbiao J Diabetes Res Research Article AIM: This study investigated the associations among early pregnancy vitamin D concentrations, seasonality, and vitamin D metabolic gene variants and how these variables related alone and in interaction with the risk of gestational diabetes mellitus (GDM). METHODS: Research participants were women from the Ma'anshan birth cohort study in China. The overall study included 3110 women to explore the association between early pregnancy vitamin D concentrations and the risk of GDM. In the current analysis, a nested case-control study of 274 GDM cases and 380 controls was conducted to investigate seven vitamin D metabolic gene variants and the risk of GDM. Vitamin D concentrations were measured by radioimmunoassay. Genotypes were determined by improved multiple ligase detection reaction. Interactions between genetic variants and vitamin D as predictors of the risk of GDM were evaluated by a pair-wise analysis under a multiplicative interaction model. RESULTS: Vitamin D concentrations were not significantly associated with the risk of GDM (OR = 0.79, 95% CI = 0.55-1.13) after adjusting for seasonality. Fall-winter conceptions had a 37% decreased risk of GDM compared with spring-summer conceptions (OR = 0.63, 95% CI = 0.49-0.81), independent of vitamin D concentrations. Two VDR gene variants rs1544410 (OR = 2.03, 95% CI = 1.17-3.51 for CT versus CC) and rs731236 (OR = 2.42, 95% CI = 1.29-4.55 for GA versus AA) were significantly associated with the risk of GDM. No interactions among genetic variants and vitamin D concentrations were detected. CONCLUSION: Early pregnancy vitamin D insufficiency or deficiency was not significantly associated with the risk of GDM. The results of this study emphasize the importance of genetic variants in VDR and conception season as factors that affect the risk of GDM. Hindawi 2019-06-24 /pmc/articles/PMC6613005/ /pubmed/31341914 http://dx.doi.org/10.1155/2019/8313901 Text en Copyright © 2019 Beibei Zhu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Beibei
Huang, Kun
Yan, Shuangqin
Hao, Jiahu
Zhu, Peng
Chen, Yao
Ye, Aoxing
Tao, Fangbiao
VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study
title VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study
title_full VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study
title_fullStr VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study
title_full_unstemmed VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study
title_short VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma'anshan Birth Cohort (MABC) Study
title_sort vdr variants rather than early pregnancy vitamin d concentrations are associated with the risk of gestational diabetes: the ma'anshan birth cohort (mabc) study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613005/
https://www.ncbi.nlm.nih.gov/pubmed/31341914
http://dx.doi.org/10.1155/2019/8313901
work_keys_str_mv AT zhubeibei vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT huangkun vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT yanshuangqin vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT haojiahu vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT zhupeng vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT chenyao vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT yeaoxing vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy
AT taofangbiao vdrvariantsratherthanearlypregnancyvitamindconcentrationsareassociatedwiththeriskofgestationaldiabetesthemaanshanbirthcohortmabcstudy