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Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors

The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglyc...

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Autores principales: Zubiri, Leyre, Bilbao, José I, Rodríguez, Javier, Sangro, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613041/
https://www.ncbi.nlm.nih.gov/pubmed/31293777
http://dx.doi.org/10.2217/hep-2017-0025
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author Zubiri, Leyre
Bilbao, José I
Rodríguez, Javier
Sangro, Bruno
author_facet Zubiri, Leyre
Bilbao, José I
Rodríguez, Javier
Sangro, Bruno
author_sort Zubiri, Leyre
collection PubMed
description The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglycemia and coma) refractory to conventional treatments, which were finally solved with selective internal radiation therapy (SIRT), a nonstandard level 1 therapy. We show two examples of an excellent control of symptoms together with a long survival after treatment with SIRT. The evidence supporting the use of this therapy is level 2. Our case reports strongly support the use of SIRT for the severe clinical syndrome in pNET metastatic to the liver and refractory to somatostatin analogs.
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spelling pubmed-66130412019-07-10 Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors Zubiri, Leyre Bilbao, José I Rodríguez, Javier Sangro, Bruno Hepat Oncol Case Series The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglycemia and coma) refractory to conventional treatments, which were finally solved with selective internal radiation therapy (SIRT), a nonstandard level 1 therapy. We show two examples of an excellent control of symptoms together with a long survival after treatment with SIRT. The evidence supporting the use of this therapy is level 2. Our case reports strongly support the use of SIRT for the severe clinical syndrome in pNET metastatic to the liver and refractory to somatostatin analogs. Future Medicine Ltd 2018-09-28 /pmc/articles/PMC6613041/ /pubmed/31293777 http://dx.doi.org/10.2217/hep-2017-0025 Text en © 2018 Leyre Zubiri This work is licensed under a Creative Commons Attribution-NonCommercial NonDerivative 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Case Series
Zubiri, Leyre
Bilbao, José I
Rodríguez, Javier
Sangro, Bruno
Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
title Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
title_full Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
title_fullStr Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
title_full_unstemmed Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
title_short Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
title_sort selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613041/
https://www.ncbi.nlm.nih.gov/pubmed/31293777
http://dx.doi.org/10.2217/hep-2017-0025
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