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Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors
The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglyc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613041/ https://www.ncbi.nlm.nih.gov/pubmed/31293777 http://dx.doi.org/10.2217/hep-2017-0025 |
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author | Zubiri, Leyre Bilbao, José I Rodríguez, Javier Sangro, Bruno |
author_facet | Zubiri, Leyre Bilbao, José I Rodríguez, Javier Sangro, Bruno |
author_sort | Zubiri, Leyre |
collection | PubMed |
description | The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglycemia and coma) refractory to conventional treatments, which were finally solved with selective internal radiation therapy (SIRT), a nonstandard level 1 therapy. We show two examples of an excellent control of symptoms together with a long survival after treatment with SIRT. The evidence supporting the use of this therapy is level 2. Our case reports strongly support the use of SIRT for the severe clinical syndrome in pNET metastatic to the liver and refractory to somatostatin analogs. |
format | Online Article Text |
id | pubmed-6613041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-66130412019-07-10 Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors Zubiri, Leyre Bilbao, José I Rodríguez, Javier Sangro, Bruno Hepat Oncol Case Series The hormone secretion in pancreatic neuroendocrine tumors (pNET) causes an important interference in patients' quality of life. We present two cases of pNET metastatic to the liver (a pancreatic endocrine carcinoma with a severe hormonal syndrome and an insulinoma with severe crisis of hypoglycemia and coma) refractory to conventional treatments, which were finally solved with selective internal radiation therapy (SIRT), a nonstandard level 1 therapy. We show two examples of an excellent control of symptoms together with a long survival after treatment with SIRT. The evidence supporting the use of this therapy is level 2. Our case reports strongly support the use of SIRT for the severe clinical syndrome in pNET metastatic to the liver and refractory to somatostatin analogs. Future Medicine Ltd 2018-09-28 /pmc/articles/PMC6613041/ /pubmed/31293777 http://dx.doi.org/10.2217/hep-2017-0025 Text en © 2018 Leyre Zubiri This work is licensed under a Creative Commons Attribution-NonCommercial NonDerivative 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Series Zubiri, Leyre Bilbao, José I Rodríguez, Javier Sangro, Bruno Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
title | Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
title_full | Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
title_fullStr | Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
title_full_unstemmed | Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
title_short | Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
title_sort | selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613041/ https://www.ncbi.nlm.nih.gov/pubmed/31293777 http://dx.doi.org/10.2217/hep-2017-0025 |
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