Cargando…

Membrane perforation by the pore-forming toxin pneumolysin

Pneumolysin (PLY), a major virulence factor of Streptococcus pneumoniae, perforates cholesterol-rich lipid membranes. PLY protomers oligomerize as rings on the membrane and then undergo a structural transition that triggers the formation of membrane pores. Structures of PLY rings in prepore and pore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vögele, Martin, Bhaskara, Ramachandra M., Mulvihill, Estefania, van Pee, Katharina, Yildiz, Özkan, Kühlbrandt, Werner, Müller, Daniel J., Hummer, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613103/ https://www.ncbi.nlm.nih.gov/pubmed/31209022 http://dx.doi.org/10.1073/pnas.1904304116

Ejemplares similares

Reply to Desikan et al.: Micelle formation among various mechanisms of toxin pore formation
por: Vögele, Martin, et al.
Publicado: (2020)

CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin
por: van Pee, Katharina, et al.
Publicado: (2017)

Incomplete pneumolysin oligomers form membrane pores
por: Sonnen, Andreas F.-P., et al.
Publicado: (2014)

Membrane Cholesterol Content and Lipid Organization Influence Melittin and Pneumolysin Pore-Forming Activity
por: Ganpule, Shamish, et al.
Publicado: (2022)

Measuring kinetic drivers of pneumolysin pore structure
por: Gilbert, Robert J. C., et al.
Publicado: (2016)

Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
por: Okazaki, Kei-ichi, et al.
Publicado: (2019)

Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus
por: D'Imprima, Edoardo, et al.
Publicado: (2017)

Bacterial pore-forming toxins
por: Ulhuq, Fatima R., et al.
Publicado: (2022)

Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-Dependent Cytolysin Pneumolysin Still Require Pore-Forming Capacity
por: Förtsch, Christina, et al.
Publicado: (2011)

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms
por: Shak, Joshua R., et al.
Publicado: (2013)

Structural Basis of the Pore-Forming Toxin/Membrane Interaction
por: Li, Yajuan, et al.
Publicado: (2021)

Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
por: Ostolaza, Helena, et al.
Publicado: (2019)

Mechanism of membrane pore formation by human gasdermin‐D
por: Mulvihill, Estefania, et al.
Publicado: (2018)

FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes
por: Siggel, Marc, et al.
Publicado: (2021)

Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation
por: Bewley, Martin A., et al.
Publicado: (2014)

Direct Transmembrane Interaction between Actin and the Pore-Competent, Cholesterol-Dependent Cytolysin Pneumolysin
por: Hupp, Sabrina, et al.
Publicado: (2013)

Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
por: Etxaniz, Asier, et al.
Publicado: (2018)

Temporary Membrane Permeabilization via the Pore-Forming Toxin Lysenin
por: Shrestha, Nisha, et al.
Publicado: (2020)

Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
por: Ernst, Katharina, et al.
Publicado: (2021)

Curcumin Inhibits Membrane-Damaging Pore-Forming Function of the β-Barrel Pore-Forming Toxin Vibrio cholerae Cytolysin
por: Singh, Mahendra, et al.
Publicado: (2022)

Ion Binding and Selectivity of the Na(+)/H(+) Antiporter MjNhaP1 from Experiment and Simulation
por: Warnau, Judith, et al.
Publicado: (2019)

The MACPF/CDC family of pore-forming toxins
por: Rosado, Carlos J, et al.
Publicado: (2008)

Role of Pore-Forming Toxins in Neonatal Sepsis
por: Sonnen, Andreas F.-P., et al.
Publicado: (2013)

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation
por: Lawrence, Sara L., et al.
Publicado: (2015)

Structure and substrate ion binding in the sodium/proton antiporter PaNhaP
por: Wöhlert, David, et al.
Publicado: (2014)

Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins
por: Reddy, Bhaskara L., et al.
Publicado: (2016)

Finite-Size-Corrected Rotational Diffusion Coefficients of Membrane Proteins and Carbon Nanotubes from Molecular Dynamics Simulations
por: Vögele, Martin, et al.
Publicado: (2019)

A biomimetic nanosponge that absorbs pore-forming toxins
por: Hu, Che-Ming J., et al.
Publicado: (2013)

Cellular Entry of Binary and Pore-Forming Bacterial Toxins
por: Ladokhin, Alexey S.
Publicado: (2017)

The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex
por: Marshall, Jamie E., et al.
Publicado: (2015)

Retinal isomerization and water-pore formation in channelrhodopsin-2
por: Ardevol, Albert, et al.
Publicado: (2018)

Pneumolysin: Pathogenesis and Therapeutic Target
por: Nishimoto, Andrew T., et al.
Publicado: (2020)

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
por: Sborgi, Lorenzo, et al.
Publicado: (2016)

Pro-autophagic signal induction by bacterial pore-forming toxins
por: Kloft, Nicole, et al.
Publicado: (2010)

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
por: Kao, Cheng-Yuan, et al.
Publicado: (2011)

Staphylococcal Bicomponent Pore-Forming Toxins: Targets for Prophylaxis and Immunotherapy
por: Aman, M. Javad, et al.
Publicado: (2014)

Insights into the Voltage Regulation Mechanism of the Pore-Forming Toxin Lysenin
por: Bryant, Sheenah Lynn, et al.
Publicado: (2018)

Response of Cellular Innate Immunity to Cnidarian Pore-Forming Toxins
por: Yap, Wei Yuen, et al.
Publicado: (2018)

Disarming Pore-Forming Toxins with Biomimetic Nanosponges in Intraocular Infections
por: Coburn, Phillip S., et al.
Publicado: (2019)

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins
por: Ormsby, Thomas J. R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_46sel9hmmjcdfod30cm6rcsks4