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Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents
Leptin informs the brain about sufficiency of fuel stores. When insufficient, leptin levels fall, triggering compensatory increases in appetite. Falling leptin is first sensed by hypothalamic neurons, which then initiate adaptive responses. With regard to hunger, it is thought that leptin-sensing ne...
Autores principales: | Perry, Rachel J., Resch, Jon M., Douglass, Amelia M., Madara, Joseph C., Rabin-Court, Aviva, Kucukdereli, Hakan, Wu, Chen, Song, Joongyu D., Lowell, Bradford B., Shulman, Gerald I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613139/ https://www.ncbi.nlm.nih.gov/pubmed/31213533 http://dx.doi.org/10.1073/pnas.1901795116 |
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