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Optimized adaptive enrichment designs
Based on a Bayesian decision theoretic approach, we optimize frequentist single- and adaptive two-stage trial designs for the development of targeted therapies, where in addition to an overall population, a pre-defined subgroup is investigated. In such settings, the losses and gains of decisions can...
Autores principales: | Ondra, Thomas, Jobjörnsson, Sebastian, Beckman, Robert A, Burman, Carl-Fredrik, König, Franz, Stallard, Nigel, Posch, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613177/ https://www.ncbi.nlm.nih.gov/pubmed/29254436 http://dx.doi.org/10.1177/0962280217747312 |
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