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Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes

The rapid rise in the prevalence of type 2 diabetes mellitus (T2DM) poses a huge healthcare burden across the world. Although there are several antihyperglycaemic agents (AHAs) available including addition of new drug classes to the treatment algorithm, more than 50% of patients with T2DM do not ach...

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Autores principales: Fujiwara, Yuki, Eguchi, Shunsuke, Murayama, Hiroki, Takahashi, Yuri, Toda, Mitsutoshi, Imai, Kota, Tsuda, Kinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613229/
https://www.ncbi.nlm.nih.gov/pubmed/31294084
http://dx.doi.org/10.1002/edm2.68
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author Fujiwara, Yuki
Eguchi, Shunsuke
Murayama, Hiroki
Takahashi, Yuri
Toda, Mitsutoshi
Imai, Kota
Tsuda, Kinsuke
author_facet Fujiwara, Yuki
Eguchi, Shunsuke
Murayama, Hiroki
Takahashi, Yuri
Toda, Mitsutoshi
Imai, Kota
Tsuda, Kinsuke
author_sort Fujiwara, Yuki
collection PubMed
description The rapid rise in the prevalence of type 2 diabetes mellitus (T2DM) poses a huge healthcare burden across the world. Although there are several antihyperglycaemic agents (AHAs) available including addition of new drug classes to the treatment algorithm, more than 50% of patients with T2DM do not achieve glycaemic targets, suggesting an urgent need for treatment strategies focusing on prevention and progression of T2DM and its long‐term complications. Lifestyle changes including implementation of healthy diet and physical activity are cornerstones for the management of T2DM. The positive effects of diet and exercise on incretin hormones such as glucagon‐like peptide‐1 (GLP‐1) have been reported. We hypothesize an IDEP concept (Interaction between Diet/Exercise and Pharmacotherapy) aimed at modifying the diet and lifestyle, along with pharmacotherapy to enhance the GLP‐1 levels, would result in good glycaemic control in patients with T2DM. Consuming protein‐rich food, avoiding saturated fatty acids and making small changes in eating habits such as eating slowly with longer mastication time can have a positive impact on the GLP‐1 secretion and insulin levels. Further the type of physical activity (aerobic/resistance training), intensity of exercise, duration, time and frequency of exercise have shown to improve GLP‐1 levels. Apart from AHAs, a few antihypertensive drugs and lipid‐lowering drugs have also shown to increase endogenous GLP‐1 levels, however, due to quick degradation of GLP‐1 by dipeptidyl peptidase‐4 (DPP‐4) enzyme, treatment with DPP‐4 inhibitors would protect GLP‐1 from degradation and prolong its activity. Thus, IDEP concept can be a promising treatment strategy, which positively influences the GLP‐1 levels and provide additive benefits in terms of improving metabolic parameters in patients with T2DM and slowing the progression of T2DM and its associated complications.
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spelling pubmed-66132292019-07-10 Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes Fujiwara, Yuki Eguchi, Shunsuke Murayama, Hiroki Takahashi, Yuri Toda, Mitsutoshi Imai, Kota Tsuda, Kinsuke Endocrinol Diabetes Metab Review Articles The rapid rise in the prevalence of type 2 diabetes mellitus (T2DM) poses a huge healthcare burden across the world. Although there are several antihyperglycaemic agents (AHAs) available including addition of new drug classes to the treatment algorithm, more than 50% of patients with T2DM do not achieve glycaemic targets, suggesting an urgent need for treatment strategies focusing on prevention and progression of T2DM and its long‐term complications. Lifestyle changes including implementation of healthy diet and physical activity are cornerstones for the management of T2DM. The positive effects of diet and exercise on incretin hormones such as glucagon‐like peptide‐1 (GLP‐1) have been reported. We hypothesize an IDEP concept (Interaction between Diet/Exercise and Pharmacotherapy) aimed at modifying the diet and lifestyle, along with pharmacotherapy to enhance the GLP‐1 levels, would result in good glycaemic control in patients with T2DM. Consuming protein‐rich food, avoiding saturated fatty acids and making small changes in eating habits such as eating slowly with longer mastication time can have a positive impact on the GLP‐1 secretion and insulin levels. Further the type of physical activity (aerobic/resistance training), intensity of exercise, duration, time and frequency of exercise have shown to improve GLP‐1 levels. Apart from AHAs, a few antihypertensive drugs and lipid‐lowering drugs have also shown to increase endogenous GLP‐1 levels, however, due to quick degradation of GLP‐1 by dipeptidyl peptidase‐4 (DPP‐4) enzyme, treatment with DPP‐4 inhibitors would protect GLP‐1 from degradation and prolong its activity. Thus, IDEP concept can be a promising treatment strategy, which positively influences the GLP‐1 levels and provide additive benefits in terms of improving metabolic parameters in patients with T2DM and slowing the progression of T2DM and its associated complications. John Wiley and Sons Inc. 2019-05-16 /pmc/articles/PMC6613229/ /pubmed/31294084 http://dx.doi.org/10.1002/edm2.68 Text en © 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Fujiwara, Yuki
Eguchi, Shunsuke
Murayama, Hiroki
Takahashi, Yuri
Toda, Mitsutoshi
Imai, Kota
Tsuda, Kinsuke
Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes
title Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes
title_full Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes
title_fullStr Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes
title_full_unstemmed Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes
title_short Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes
title_sort relationship between diet/exercise and pharmacotherapy to enhance the glp‐1 levels in type 2 diabetes
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613229/
https://www.ncbi.nlm.nih.gov/pubmed/31294084
http://dx.doi.org/10.1002/edm2.68
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