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RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma

BACKGROUND: In epithelial cells, tyrosine kinases induce tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which is responsible for the epithelial-mesenchymal transition (EMT). However, the precise mechanisms remain unclear. METHODS: Protein antibody microarray analysis and E3 l...

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Detalles Bibliográficos
Autores principales:	Zhang, Yunfeng, Sun, Liangzhang, Gao, Xiao, Guo, Aining, Diao, Yan, Zhao, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613270/ https://www.ncbi.nlm.nih.gov/pubmed/31286874 http://dx.doi.org/10.1186/s12885-019-5880-1

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