Prognostic significance of periostin in colorectal cancer

Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is obs...

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Detalles Bibliográficos
Autores principales: Deng, Xingming, Ao, Sheng, Hou, Jianing, Li, Zhuofei, Lei, Yunpeng, Lyu, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613499/
https://www.ncbi.nlm.nih.gov/pubmed/31354223
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.03.16
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author Deng, Xingming
Ao, Sheng
Hou, Jianing
Li, Zhuofei
Lei, Yunpeng
Lyu, Guoqing
author_facet Deng, Xingming
Ao, Sheng
Hou, Jianing
Li, Zhuofei
Lei, Yunpeng
Lyu, Guoqing
author_sort Deng, Xingming
collection PubMed
description Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC.
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spelling pubmed-66134992019-07-26 Prognostic significance of periostin in colorectal cancer Deng, Xingming Ao, Sheng Hou, Jianing Li, Zhuofei Lei, Yunpeng Lyu, Guoqing Chin J Cancer Res Review Article Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC. AME Publishing Company 2019-06 /pmc/articles/PMC6613499/ /pubmed/31354223 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.03.16 Text en Copyright © 2019 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review Article
Deng, Xingming
Ao, Sheng
Hou, Jianing
Li, Zhuofei
Lei, Yunpeng
Lyu, Guoqing
Prognostic significance of periostin in colorectal cancer
title Prognostic significance of periostin in colorectal cancer
title_full Prognostic significance of periostin in colorectal cancer
title_fullStr Prognostic significance of periostin in colorectal cancer
title_full_unstemmed Prognostic significance of periostin in colorectal cancer
title_short Prognostic significance of periostin in colorectal cancer
title_sort prognostic significance of periostin in colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613499/
https://www.ncbi.nlm.nih.gov/pubmed/31354223
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.03.16
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AT leiyunpeng prognosticsignificanceofperiostinincolorectalcancer
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