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Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase

OBJECTIVE: Tumor cells rely heavily on glycolysis regardless of oxygen tension, a phenomenon called the Warburg effect. Hexokinase II (HKII) catalyzes the first irreversible step of glycolysis and is often overexpressed in tumor cells. Mitochondrial HKII couples glycolysis and oxidative phosphorylat...

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Detalles Bibliográficos
Autores principales:	Luo, Fangxiu, Li, You, Yuan, Fei, Zuo, Junli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613503/ https://www.ncbi.nlm.nih.gov/pubmed/31354221 http://dx.doi.org/10.21147/j.issn.1000-9604.2019.03.14

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