Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

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Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG) accumulation, the metabolic consequences of these...

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Detalles Bibliográficos
Autores principales: Badur, Mehmet G., Muthusamy, Thangaselvam, Parker, Seth J., Ma, Shenghong, McBrayer, Samuel K., Cordes, Thekla, Magana, Jose H., Guan, Kun-Liang, Metallo, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613636/
https://www.ncbi.nlm.nih.gov/pubmed/30355481
http://dx.doi.org/10.1016/j.celrep.2018.09.074
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