A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen...

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Detalles Bibliográficos
Autores principales: Brimacombe, Cedric A., Burke, Jordan E., Parsa, Jahan-Yar, Catania, Sandra, O’Meara, Teresa R., Witchley, Jessica N., Burrack, Laura S., Madhani, Hiten D., Noble, Suzanne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613695/
https://www.ncbi.nlm.nih.gov/pubmed/31226107
http://dx.doi.org/10.1371/journal.pbio.3000331

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