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Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis

Analysis of temperature-sensitive (ts) mutant viruses is a classic method allowing researchers to identify genetic loci involved in viral replication and pathogenesis. Here, we report genetic analysis of a ts strain of mouse hepatitis virus (MHV), tsNC11, focusing on the role of mutations in the mac...

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Detalles Bibliográficos
Autores principales:	Deng, Xufang, Mettelman, Robert C., O’Brien, Amornrat, Thompson, John A., O’Brien, Timothy E., Baker, Susan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613754/ https://www.ncbi.nlm.nih.gov/pubmed/30918076 http://dx.doi.org/10.1128/JVI.02140-18

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