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Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3′-Terminal Adenylyltransferase Activity

Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and found that the protein has metal ion-dependent RNA 3...

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Detalles Bibliográficos
Autores principales:	Tvarogová, Jana, Madhugiri, Ramakanth, Bylapudi, Ganesh, Ferguson, Lyndsey J., Karl, Nadja, Ziebuhr, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613758/ https://www.ncbi.nlm.nih.gov/pubmed/30918070 http://dx.doi.org/10.1128/JVI.00291-19

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