CCR5-Δ32 is deleterious in the homozygous state in humans

We use the genotyping and death register information of 409,693 British individuals to investigate fitness effects of the CCR5-Δ32 mutation. We estimate that individuals homozygous for the Δ32 allele have a 21% increase in all-cause mortality rate. A deleterious effect of the Δ32/Δ32 mutation is als...

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Detalles Bibliográficos
Autores principales: Wei, Xinzhu, Nielsen, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613792/
https://www.ncbi.nlm.nih.gov/pubmed/31160814
http://dx.doi.org/10.1038/s41591-019-0459-6
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author Wei, Xinzhu
Nielsen, Rasmus
author_facet Wei, Xinzhu
Nielsen, Rasmus
author_sort Wei, Xinzhu
collection PubMed
description We use the genotyping and death register information of 409,693 British individuals to investigate fitness effects of the CCR5-Δ32 mutation. We estimate that individuals homozygous for the Δ32 allele have a 21% increase in all-cause mortality rate. A deleterious effect of the Δ32/Δ32 mutation is also independently supported by a significant deviation from Hardy-Weinberg equilibrium due to a deficiency of Δ32/Δ32 individuals at the time of recruitment.
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spelling pubmed-66137922019-12-04 CCR5-Δ32 is deleterious in the homozygous state in humans Wei, Xinzhu Nielsen, Rasmus Nat Med Article We use the genotyping and death register information of 409,693 British individuals to investigate fitness effects of the CCR5-Δ32 mutation. We estimate that individuals homozygous for the Δ32 allele have a 21% increase in all-cause mortality rate. A deleterious effect of the Δ32/Δ32 mutation is also independently supported by a significant deviation from Hardy-Weinberg equilibrium due to a deficiency of Δ32/Δ32 individuals at the time of recruitment. 2019-06-03 2019-06 /pmc/articles/PMC6613792/ /pubmed/31160814 http://dx.doi.org/10.1038/s41591-019-0459-6 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wei, Xinzhu
Nielsen, Rasmus
CCR5-Δ32 is deleterious in the homozygous state in humans
title CCR5-Δ32 is deleterious in the homozygous state in humans
title_full CCR5-Δ32 is deleterious in the homozygous state in humans
title_fullStr CCR5-Δ32 is deleterious in the homozygous state in humans
title_full_unstemmed CCR5-Δ32 is deleterious in the homozygous state in humans
title_short CCR5-Δ32 is deleterious in the homozygous state in humans
title_sort ccr5-δ32 is deleterious in the homozygous state in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613792/
https://www.ncbi.nlm.nih.gov/pubmed/31160814
http://dx.doi.org/10.1038/s41591-019-0459-6
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