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CCR5-Δ32 is deleterious in the homozygous state in humans
We use the genotyping and death register information of 409,693 British individuals to investigate fitness effects of the CCR5-Δ32 mutation. We estimate that individuals homozygous for the Δ32 allele have a 21% increase in all-cause mortality rate. A deleterious effect of the Δ32/Δ32 mutation is als...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613792/ https://www.ncbi.nlm.nih.gov/pubmed/31160814 http://dx.doi.org/10.1038/s41591-019-0459-6 |