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Basement membrane and blood–brain barrier
The blood–brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane (BM). The vast majority of BBB research focuses on its cellular constituents. Its non-cellular component, the BM, on the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613871/ https://www.ncbi.nlm.nih.gov/pubmed/31338215 http://dx.doi.org/10.1136/svn-2018-000198 |
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author | Xu, Lingling Nirwane, Abhijit Yao, Yao |
author_facet | Xu, Lingling Nirwane, Abhijit Yao, Yao |
author_sort | Xu, Lingling |
collection | PubMed |
description | The blood–brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane (BM). The vast majority of BBB research focuses on its cellular constituents. Its non-cellular component, the BM, on the other hand, is largely understudied due to its intrinsic complexity and the lack of research tools. In this review, we focus on the role of the BM in BBB integrity. We first briefly introduce the biochemical composition and structure of the BM. Next, the biological functions of major components of the BM in BBB formation and maintenance are discussed. Our goal is to provide a concise overview on how the BM contributes to BBB integrity. |
format | Online Article Text |
id | pubmed-6613871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-66138712019-07-23 Basement membrane and blood–brain barrier Xu, Lingling Nirwane, Abhijit Yao, Yao Stroke Vasc Neurol Review The blood–brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane (BM). The vast majority of BBB research focuses on its cellular constituents. Its non-cellular component, the BM, on the other hand, is largely understudied due to its intrinsic complexity and the lack of research tools. In this review, we focus on the role of the BM in BBB integrity. We first briefly introduce the biochemical composition and structure of the BM. Next, the biological functions of major components of the BM in BBB formation and maintenance are discussed. Our goal is to provide a concise overview on how the BM contributes to BBB integrity. BMJ Publishing Group 2018-12-05 /pmc/articles/PMC6613871/ /pubmed/31338215 http://dx.doi.org/10.1136/svn-2018-000198 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Xu, Lingling Nirwane, Abhijit Yao, Yao Basement membrane and blood–brain barrier |
title | Basement membrane and blood–brain barrier |
title_full | Basement membrane and blood–brain barrier |
title_fullStr | Basement membrane and blood–brain barrier |
title_full_unstemmed | Basement membrane and blood–brain barrier |
title_short | Basement membrane and blood–brain barrier |
title_sort | basement membrane and blood–brain barrier |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613871/ https://www.ncbi.nlm.nih.gov/pubmed/31338215 http://dx.doi.org/10.1136/svn-2018-000198 |
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