Non-coding RNA and neuroinflammation: implications for the therapy of stroke

Stroke is the major leading cause of death and serious, long-term disability with major economic consequences. At present, the lack of rapid diagnostic, prognostic biomarkers and effective treatment methods are two major challenges facing stroke. Circular RNAs (circRNAs) are potential clinical bioma...

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Detalles Bibliográficos
Autores principales: Shen, Ling, Bai, Ying, Han, Bing, Yao, Honghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613872/
https://www.ncbi.nlm.nih.gov/pubmed/31338219
http://dx.doi.org/10.1136/svn-2018-000206
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author Shen, Ling
Bai, Ying
Han, Bing
Yao, Honghong
author_facet Shen, Ling
Bai, Ying
Han, Bing
Yao, Honghong
author_sort Shen, Ling
collection PubMed
description Stroke is the major leading cause of death and serious, long-term disability with major economic consequences. At present, the lack of rapid diagnostic, prognostic biomarkers and effective treatment methods are two major challenges facing stroke. Circular RNAs (circRNAs) are potential clinical biomarkers in central nervous system diseases. However, the potential role of circRNAs in neuroinflammation and neuron functional recovery in acute ischaemic stroke (AIS) remains largely unknown. This review aimed to give an overview of the function of circRNAs in AIS and summarise the latest achievements in this field.
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spelling pubmed-66138722019-07-23 Non-coding RNA and neuroinflammation: implications for the therapy of stroke Shen, Ling Bai, Ying Han, Bing Yao, Honghong Stroke Vasc Neurol Review Stroke is the major leading cause of death and serious, long-term disability with major economic consequences. At present, the lack of rapid diagnostic, prognostic biomarkers and effective treatment methods are two major challenges facing stroke. Circular RNAs (circRNAs) are potential clinical biomarkers in central nervous system diseases. However, the potential role of circRNAs in neuroinflammation and neuron functional recovery in acute ischaemic stroke (AIS) remains largely unknown. This review aimed to give an overview of the function of circRNAs in AIS and summarise the latest achievements in this field. BMJ Publishing Group 2019-03-02 /pmc/articles/PMC6613872/ /pubmed/31338219 http://dx.doi.org/10.1136/svn-2018-000206 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Shen, Ling
Bai, Ying
Han, Bing
Yao, Honghong
Non-coding RNA and neuroinflammation: implications for the therapy of stroke
title Non-coding RNA and neuroinflammation: implications for the therapy of stroke
title_full Non-coding RNA and neuroinflammation: implications for the therapy of stroke
title_fullStr Non-coding RNA and neuroinflammation: implications for the therapy of stroke
title_full_unstemmed Non-coding RNA and neuroinflammation: implications for the therapy of stroke
title_short Non-coding RNA and neuroinflammation: implications for the therapy of stroke
title_sort non-coding rna and neuroinflammation: implications for the therapy of stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613872/
https://www.ncbi.nlm.nih.gov/pubmed/31338219
http://dx.doi.org/10.1136/svn-2018-000206
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