Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function

Mutations in the γ-secretase complex are strongly associated with familial Alzheimer disease. Both proteolytic and non-proteolytic functions for the γ-secretase complex have been previously described in mammalian model organisms, but their relative contributions to disease pathology remain unclear....

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Detalles Bibliográficos
Autores principales: Sharma, Devdutt, Otto, Grant, Warren, Eleanor C., Beesley, Philip, King, Jason S., Williams, Robin S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613883/
https://www.ncbi.nlm.nih.gov/pubmed/30806144
http://dx.doi.org/10.1080/15548627.2019.1586245

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