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Microglial activation after ischaemic stroke
Ischaemic stroke can induce rapid activation of microglia. As the resident immune cells of the central nervous system, microglial activation is believed to play a central role in neuroinflammation and pathological progression of ischaemic tissue. The activation of microglia after ischaemia involves...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613941/ https://www.ncbi.nlm.nih.gov/pubmed/31338213 http://dx.doi.org/10.1136/svn-2018-000196 |
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author | Zhang, Shengxiang |
author_facet | Zhang, Shengxiang |
author_sort | Zhang, Shengxiang |
collection | PubMed |
description | Ischaemic stroke can induce rapid activation of microglia. As the resident immune cells of the central nervous system, microglial activation is believed to play a central role in neuroinflammation and pathological progression of ischaemic tissue. The activation of microglia after ischaemia involves several stereotypical events including morphological transformation, proliferation and polarisation. Studies using confocal or two-photon imaging techniques have revealed that the degree of microglial activation is correlated with the degree of ischaemia. Activated microglia display diverse polarisation phenotypes. It remains largely unclear regarding whether activated microglia are beneficial or detrimental to poststroke recovery. This mini-review focuses on the morphological and functional aspects of microglial activation, with particular attention to progress in two-photon imaging studies. |
format | Online Article Text |
id | pubmed-6613941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-66139412019-07-23 Microglial activation after ischaemic stroke Zhang, Shengxiang Stroke Vasc Neurol Review Ischaemic stroke can induce rapid activation of microglia. As the resident immune cells of the central nervous system, microglial activation is believed to play a central role in neuroinflammation and pathological progression of ischaemic tissue. The activation of microglia after ischaemia involves several stereotypical events including morphological transformation, proliferation and polarisation. Studies using confocal or two-photon imaging techniques have revealed that the degree of microglial activation is correlated with the degree of ischaemia. Activated microglia display diverse polarisation phenotypes. It remains largely unclear regarding whether activated microglia are beneficial or detrimental to poststroke recovery. This mini-review focuses on the morphological and functional aspects of microglial activation, with particular attention to progress in two-photon imaging studies. BMJ Publishing Group 2019-05-10 /pmc/articles/PMC6613941/ /pubmed/31338213 http://dx.doi.org/10.1136/svn-2018-000196 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Zhang, Shengxiang Microglial activation after ischaemic stroke |
title | Microglial activation after ischaemic stroke |
title_full | Microglial activation after ischaemic stroke |
title_fullStr | Microglial activation after ischaemic stroke |
title_full_unstemmed | Microglial activation after ischaemic stroke |
title_short | Microglial activation after ischaemic stroke |
title_sort | microglial activation after ischaemic stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613941/ https://www.ncbi.nlm.nih.gov/pubmed/31338213 http://dx.doi.org/10.1136/svn-2018-000196 |
work_keys_str_mv | AT zhangshengxiang microglialactivationafterischaemicstroke |